Paracardial fat and vitamin A: a mechanism for regulating exercise performance

Joseph, Leroy C.; Morrow, John

doi:10.1172/jci145969

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…Regular exercise, such as resistance ladder-climbing exercise, running-wheel exercise at a constant speed of 18 m/min for 60 min daily, 5 d/wk for 8 wk, has been shown to induce significant alterations in the morphology and function of AT, particularly in response to metabolic diseases. These changes include an increase in fat browning, a reduction in adipocyte hypertrophy, and improvements in glucose and lipid metabolism in AT [ 69 , 70 , 71 , 72 ]. Moreover, 2-week running-wheel exercise training not only triggers a phenotypic transformation of AT, shifting it from primarily storing energy as white adipocytes to thermogenic beige adipocytes, especially in the context of obesity and diabetes.…”

Section: The Potential Role Of Regular Exercise In Aged Adipose Tissuementioning

confidence: 99%

“…Nevertheless, regular exercise can enhance the secretion of adipokines and mitigate the morphology and function of AT in response to metabolic diseases. This includes promoting fat browning, reducing adipocyte hypertrophy, improving FFA oxidation, insulin resistance, and enhancing mitochondrial homeostasis in aging AT [ 69 , 70 , 71 , 72 ].…”

Section: Effect Of Exercise-induced Adipokine In Aged Adipose Tissuementioning

confidence: 99%

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Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Jia,

Zhang,

Liu

et al. 2024

Metabolites

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Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.

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Section: The Potential Role Of Regular Exercise In Aged Adipose Tissuementioning

confidence: 99%

Section: Effect Of Exercise-induced Adipokine In Aged Adipose Tissuementioning

confidence: 99%

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Jia,

Zhang,

Liu

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

“…Regular exercise and physical activity have been shown to induce significant alterations in the morphology and function of AT, particularly in response to metabolic diseases. These changes include an increase in fat browning, a reduction in adipocyte hypertrophy, and improvements in glucose and lipid metabolism in AT [67][68][69][70] . Moreover, regular exercise not only triggers a phenotypic transformation of AT, shifting it from primarily storing energy as white adipocytes to thermogenic beige adipocytes, especially in the context of obesity and diabetes.…”

Section: The Potential Role Of Regular Exercise In Aged Adipose Tissuementioning

confidence: 99%

Section: Effect Of Exercise-induced Adipokine In Aged Adipose Tissuementioning

confidence: 99%

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Jia,

Zhang,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. The goal of this review is to offer a comprehensive overview of the benefits of regular exercise in addressing the age-related decline in adipose tissue function. The significance of regular exercise in mitigating metabolic disorders associated with aged adipose tissue will be discussed.

show abstract

Paracardial fat and vitamin A: a mechanism for regulating exercise performance

Cited by 2 publications

References 16 publications

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

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