Paracoccidioidomicose crônica multifocal tendo como primeira manifestação o envolvimento palpebral: relato de caso

Abstract

Ocular involvement of paracoccidioidomycosis is rare and when it occurs it is usually secondary to hematogenic dissemination. A case of multifocal paracoccidioidomycosis in a 73 year-old male after history of blunt trauma in the right eye with a stick of wood that presented as the first clinical sign a lid-conjunctival lesion is described. The possible primary ocular infection spreading by contiguity is argued and the disease manifestation in an advanced age is highlighted.

Paracoccidioidomycosis in a Renal Transplant Recipient

“…Brazil is the country with the largest number of cases of the disease, with an estimated incidence ranging between 10-30 cases/million of inhabitants, and a mortality rate of 1.4 deaths/million of inhabitants. PCM diagnosis is based on clinical symptoms, direct microscopic examination of clinical specimens, isolation of fungus in culture, and detection of specific antibodies by serological techniques 4 , 6 .…”

“…However, such mycosis is rare in organ transplant recipients. There have only been three cases reported in literature, until now, that presented such mycosis complicating the transplantation of solid organs, all of which being renal transplant recipients 2 , 4 , 5 .…”

Fungal Colitis by Paracoccidioides brasiliensis: a case report

“…Unlike other types of mycosis, it is not usually related to immunodepressant diseases, although cases have been observed in association with infection by HIV, neoplasms and, more rarely, transplantation of organs 5 . The disease presents a wide spectrum of clinical manifestations, from benign local disease to multifocal systemic conditions, of difficult treatment and potentially life threatening 7 .…”

“…Paracoccidioidomycosis (PBM) is a granulomatous systemic mycosis of subacute or chronic progress, caused by a dimorphic fungus called Paracoccidioides brasiliensis [1][2][3][4][5][6][7] , known due to its microscopic aspect of a "pilot's wheel". The disease was first described in 1908 by Adolfo Lutz; in 1930, Floriano Paulo de Almeida named it Paracoccidioides brasiliensis.…”

“…PBM is considered the most important fungal infection in Latin America, with the incidence of 1 to 3 per 100,000 inhabitants in endemic areas 2 , occurring from Southern Mexico to Northern Argentina 7 . Individuals affected by the disease are mostly men who live and/or develop activities in rural areas 1,8 , between 30 and 59 years old [4][5][6]9 . The social and economic costs incurred with the debilitation of individuals in their most productive phase and extended treatment, as well as the frequent sequelae that can lead to early death when not opportunely diagnosed and treated 10,11 , ensure high epidemiological relevance to this pathology.…”