Paradoxical False Memory for Objects After Brain Damage

McTighe, Stephanie M.; Cowell, Rosemary A.; Winters, Boyer D.; Bussey, Timothy J.; Saksida, Lisa M.

doi:10.1126/science.1194780

Cited by 129 publications

(214 citation statements)

References 25 publications

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“…The observation that top-down feedback from PRC suppressed part-based responses in lower-level visual regions is consistent with a recent series of findings suggesting that the PRC may be critical in resolving perceptual interference (McTighe et al, 2010;Burke et al, 2010;Romberg et al, 2012;Barense et al, 2012;Newsome et al, 2012). For example, patients with PRC damage were impaired at perceptual discrimination under conditions of high visual interference (a series of complex object discriminations for which object parts were repeatedly presented across trials), but performed normally under conditions of low visual interference (fewer object parts repeated across trials) Newsome et al, 2012).…”

Section: Visual Cortex Activationsupporting

confidence: 75%

“…As a result of this interaction familiarity/novelty responses in lower-level visual regions and higherlevel MTL regions are coordinated to drive a coherent behavioral response. This feedback interpretation builds on evidence that the PRC discriminates between novel and familiar objects (Xiang and Brown, 1998;Henson et al, 2003;Kohler et al, 2005;Albasser et al, 2010;Burke et al, 2010;McTighe et al, 2010). The feedback framework explains why effects of part familiarity cannot be observed independently of effects of configuration familiarity in behavioral tasks conducted with nonbrain-damaged participants: when the PRC is intact, part familiarity responses at lower-levels are suppressed when familiar parts appear in Part-Rearranged Novel Configurations.…”

Section: Introductionmentioning

confidence: 99%

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The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

Peterson¹,

Cacciamani²,

Barense³

et al. 2012

Hippocampus

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ABSTRACT:Research has demonstrated that the perirhinal cortex (PRC) represents complex object-level feature configurations, and participates in familiarity versus novelty discrimination. Barense et al. [(in press) Cerebral Cortex, 22:11, doi:10.1093/cercor/bhr347] postulated that, in addition, the PRC modulates part familiarity responses in lower-level visual areas. We used fMRI to measure activation in the PRC and V2 in response to silhouettes presented peripherally while participants maintained central fixation and performed an object recognition task. There were three types of silhouettes: Familiar Configurations portrayed realworld objects; Part-Rearranged Novel Configurations created by spatially rearranging the parts of the familiar configurations; and Control Novel Configurations in which both the configuration and the ensemble of parts comprising it were novel. For right visual field (RVF) presentation, BOLD responses revealed a significant linear trend in bilateral BA 35 of the PRC (highest activation for Familiar Configurations, lowest for Part-Rearranged Novel Configurations, with Control Novel Configurations in between). For left visual field (LVF) presentation, a significant linear trend was found in a different area (bilateral BA 38, temporal pole) in the opposite direction (Part-Rearranged Novel Configurations highest, Familiar Configurations lowest). These data confirm that the PRC is sensitive to the agreement in familiarity between the configuration level and the part level. As predicted, V2 activation mimicked that of the PRC: for RVF presentation, activity in V2 was significantly higher in the left hemisphere for Familiar Configurations than for Part-Rearranged Novel Configurations, and for LVF presentation, the opposite effect was found in right hemisphere V2. We attribute these patterns in V2 to feedback from the PRC because receptive fields in V2 encompass parts but not configurations. These results reveal two new aspects of PRC function: (1) it is sensitive to the congruency between the familiarity of object configurations and the parts comprising those configurations and (2) it likely modulates familiarity responses in visual area V2. V V C 2012 Wiley Periodicals, Inc.

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Section: Visual Cortex Activationsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

Peterson¹,

Cacciamani²,

Barense³

et al. 2012

Hippocampus

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“…Lesions of the perirhinal cortex have been shown to impair performance in the object recognition task (Ennaceur et al, 1996;) and more recent work has shown that the perirhinal cortex is required for the encoding, consolidation and retrieval of object recognition memory (Winters and Bussey, 2005a,b;Winters et al, 2008). Yet, recently it has been suggested that perirhinal lesions do not impair memory formation but may instead cause the occurrence of false memories; rats with perirhinal cortex lesions show a number of false positive hits on a modified version of the object recognition task as they treated novel objects as familiar (McTighe et al, 2010). McTighe et al (2010) also demonstrated that this false memory was due to interference between the training and testing phases of the task; putting the rats in a visually restrictive environment restored the perirhinal cortex lesioned rats to the same levels of object exploration as the controls.…”

Section: Object Recognition Memorymentioning

confidence: 99%

“…Yet, recently it has been suggested that perirhinal lesions do not impair memory formation but may instead cause the occurrence of false memories; rats with perirhinal cortex lesions show a number of false positive hits on a modified version of the object recognition task as they treated novel objects as familiar (McTighe et al, 2010). McTighe et al (2010) also demonstrated that this false memory was due to interference between the training and testing phases of the task; putting the rats in a visually restrictive environment restored the perirhinal cortex lesioned rats to the same levels of object exploration as the controls.…”

Section: Object Recognition Memorymentioning

confidence: 99%

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

107

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“…Research has revealed a central role for the perirhinal cortex (PRh) in object representation (Buckley and Gaffan, 2006;Barker et al, 2007;Bartko et al, 2007;Bussey and Saksida, 2007;McTighe et al, 2010). Indeed, studies with the spontaneous object recognition (SOR) task for rats have implicated PRh in object memory encoding, consolidation, and retrieval (Winters and Bussey, 2005a,b;Barker et al, 2006a,b).…”

Section: Introductionmentioning

confidence: 99%

On the Dynamic Nature of the Engram: Evidence for Circuit-Level Reorganization of Object Memory Traces following Reactivation

Winters¹,

Tucci²,

Jacklin³

et al. 2011

J. Neurosci.

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Research has implicated the perirhinal cortex (PRh) in several aspects of object recognition memory. The specific role of the hippocampus (HPC) remains controversial, but its involvement in object recognition may pertain to processing contextual information in relation to objects rather than object representation per se. Here we investigated the roles of the PRh and HPC in object memory reconsolidation using the spontaneous object recognition task for rats. Intra-PRh infusions of the protein synthesis inhibitor anisomycin immediately following memory reactivation prevented object memory reconsolidation. Similar deficits were observed when a novel object or a salient contextual change was introduced during the reactivation phase. Intra-HPC infusions of anisomycin, however, blocked object memory reconsolidation only when a contextual change was introduced during reactivation. Moreover, disrupting functional interaction between the HPC and PRh by infusing anisomycin unilaterally into each structure in opposite hemispheres also impaired reconsolidation when reactivation was done in an altered context. These results show for the first time that the PRh is critical for reconsolidation of object memory traces and provide insight into the dynamic process of object memory storage; the selective requirement for hippocampal involvement following reactivation in an altered context suggests a substantial circuit level object trace reorganization whereby an initially PRh-dependent object memory becomes reliant on both the HPC and PRh and their interaction. Such trace reorganization may play a central role in reconsolidation-mediated memory updating and could represent an important aspect of lingering consolidation processes proposed to underlie long-term memory modulation and stabilization.

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Paradoxical False Memory for Objects After Brain Damage

Cited by 129 publications

References 25 publications

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

On the Dynamic Nature of the Engram: Evidence for Circuit-Level Reorganization of Object Memory Traces following Reactivation

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