Paradoxical response to cerulein on sphincter of Oddi in the patient with gastrectomy

Odani, Katsuyoshi; Nimura, Yuji; Yasui, Akihiro; Akita, Yukihiko; Shionoya, Shigehiko

doi:10.1007/bf01300389

Cited by 13 publications

(13 citation statements)

References 19 publications

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“…31 This paradoxical response is also observed in patients with gastrectomy, and in conscious dogs with proximal duodenal transection. 9,12,13 Our present study has found, for the first time, that the paradoxical response is not mediated by CCK receptors on the SO smooth muscle, but may be mediated by a mechanism requiring SOduodenal myoneural continuity.…”

Section: Discussionsupporting

confidence: 46%

Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

et al. 2005

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Section: Discussionsupporting

confidence: 46%

Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

et al. 2005

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“…[31][32][33] Our recent study showed that CCK exhibited a "paradoxical" response of contraction instead of relaxation after proximal duodenal transection and anastomosis in conscious dogs. 34 In postgastrectomy patients, Odani et al 17 also observed the paradoxical SO response to cerulein. In the present study, truncal vagotomy failed to change the effect of CCK on the SO basal pressure and amplitude.…”

Section: Discussionmentioning

confidence: 97%

“…14 The inhibitory effect of cerulein, an analogue of CCK, on the human SO reverses to excitation after gastrectomy. 17 Although CCK has a direct excitatory effect on gut smooth muscle, there is another CCK-sensitive inhibitory pathway in the SO. [31][32][33] Our recent study showed that CCK exhibited a "paradoxical" response of contraction instead of relaxation after proximal duodenal transection and anastomosis in conscious dogs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Truncal Vagotomy on Sphincter of Oddi Cyclic Motility in Conscious Dogs

Nabae

Yokohata

Otsuka³

et al. 2002

Annals of Surgery

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ObjectiveTo evaluate the effects of truncal vagotomy at the diaphragmatic level on the sphincter of Oddi (SO) motility. Summary Background DataCholelithiasis is a well-known late complication after gastrectomy and/or vagotomy. The mechanism of gallstone formation is only partly understood, and few studies address the effects of vagotomy on SO cyclic motility in conscious subjects. MethodsIn conscious dogs, SO motility was recorded by retrograde infusion manometry through a duodenal cannula before and after bilateral truncal vagotomy at the diaphragmatic level. Effects of cholecystokinin-octapeptide and feeding were also evaluated before and after vagotomy. ResultsSO cyclic motility and the gastroduodenal migrating motor complex continued to occur during postvagotomy fasting. Intermittent inhibitions of the SO and duodenal contractions disappeared during phase 3 of the migrating motor complex. SO basal pressure significantly decreased, whereas the amplitude significantly increased. Cholecystokinin-octapeptide inhibited SO contractions before and after vagotomy. The amplitude of SO contractions increased and their frequency decreased after feeding; however, these effects disappeared after vagotomy. ConclusionsSO cyclic motility and the effects of feeding change after truncal vagotomy at the diaphragmatic level. These facts may at least partly explain gallstone formation after gastric surgery and/or vagotomy.

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“…Direct neural pathways couple the duodenum with the gallbladder and SO, and the SO with the gallbladder. Several surgical procedures,such as gastrectomy [9] , vagotomy [10] and cholecystectomy [11,12] have been known to alter SO motility by disrupting certain aspects of the innervations. Numerous reports described SO motility after transection or electrical stimulation of extrinsic nerves,such as the vagal and splanchnic nerves [13][14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Yuan²,

Cheng³

et al. 2003

WJG

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AIM: Several neural and hormonal factors are known to affect motility of sphincter of Oddi (SO). The major roles of SO are to regulate the flow of bile and pancreatic juice into the duodenum and to prevent the reflux of duodenal contents into the biliary and pancreatic duct. After pancreas transplantation, graft SO was denervated and graft pancreatitis might have relations to SO motility. The motility of SO after canine pancreas transplantation with bladder drainage was investigated. METHODS:Normal canine SO manometry and pancreas graft SO manometry after pancreas transplantation with bladder drainage were performed in seven dogs respectively before and after cholecystokinin (CCK) administration. Data of SO basal pressure, contraction frequency, amplitude and motility index after transplantation and CCK administration were compared with that in controls and before CCK administration.RESULTS: SO showed regular contractions with a certain basal pressure in control dogs. After transplantation, the graft SO basal pressure and contraction frequency were higher than that in controls, but the amplitude decreased (P<0.01). There was no great difference in SO motility index. CCK administration could relax normal SO but stimulate graft SO after pancreas transplantation with bladder drainage. After CCK administration, SO basal pressure, frequency and motility index were increased significantly (P<0.05), in comparison with that before administration. The amplitude remained unchanged (P>0.05), in comparison with that before CCK administration. CONCLUSION:After auto-pancreas transplantation with bladder drainage, canine SO motility was inhibited. Basal pressure and frequency increased but amplitude decreased. CCK administration after transplantation had an inhibitory effect on canine SO instead of a relaxation effect observed in normal canine SO. This will increase the resistance of SO to the pancreatic juice flow and induce pancreatic juice stagnation and can not prevent reflux of urine and duodenal contents when the bladder pressure is increased to a certain extent, which may cause graft pancreatitis.Li GC, Yuan CH, Cheng Y, Liu YF. Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage.

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Paradoxical response to cerulein on sphincter of Oddi in the patient with gastrectomy

Cited by 13 publications

References 19 publications

Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

Effect of Truncal Vagotomy on Sphincter of Oddi Cyclic Motility in Conscious Dogs

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

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