Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer

Tang, Jianjun; Wang, Gang; Zhang, Meifang; Li, Fengyan; Sang, Yi; Wang, Boqing; Hu, Kaishun; Wu, Yuanzhong; Luo, Rongzhen; Liao, Dan; Jie, Cao; Wang, Xinxin; Wang, Lili; Zhang, Ruhua; Zhang, Xiaoshi; Deng, Wuguo; Xie, Dan; Xu, Rui‐Hua; Kang, Tiebang

doi:10.18632/oncotarget.2502

Cited by 51 publications

(72 citation statements)

References 47 publications

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“…A recent study showed that depletion of CBX8 delays cell cycle progression and results in the inhibition of proliferation of CRC by the p53 pathway . We wondered whether a similar pathway is involved in UCB when CBX8 is depleted.…”

Section: Resultsmentioning

confidence: 98%

“…In addition, CBX8 directly binds to the INK4A‐ARF locus to promote cell proliferation and to bypass senescence . Recent reports have shown that CBX8 is positively associated with glioblastoma, colorectal cancer, and leukemia . For example, CBX8 upregulation is associated with TNM staging in esophageal carcinoma, and it acts as a novel DNA repair protein that promotes cell proliferation and protects cancer cells from sensitivity to ionizing radiation or hydrogen peroxide .…”

mentioning

confidence: 99%

“…(11,12) Recent reports have shown that CBX8 is positively associated with glioblastoma, colorectal cancer, and leukemia. (13)(14)(15) For example, CBX8 upregulation is associated with TNM staging in esophageal carcinoma, and it acts as a novel DNA repair protein that promotes cell proliferation and protects cancer cells from sensitivity to ionizing radiation or hydrogen peroxide. (16) Knockdown of CBX8 inhibits cell proliferation and cell cycle progression by increasing the phosphorylation of p21, Wee1, and CHK1.…”

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confidence: 99%

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Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

et al. 2017

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Chromobox homolog 8 (CBX8), also known as human polycomb 8, is a repressor that maintains the transcriptionally repressive state in various cellular genes, and has been reported to promote tumorigenesis. In the present study, we examined CBX8 expression in eight pairs of muscle invasive bladder cancer tissues and adjacent non‐tumor tissues, and found that CBX8 was frequently upregulated in muscle invasive bladder cancer tissues when compared to adjacent non‐tumor tissues. Analysis showed that high expression of CBX8 in 152 muscle invasive bladder cancer specimens was associated with progression of the T, N, and M stages (P = 0.004, 0.005, <0.001, respectively). Furthermore, Kaplan–Meier survival analysis and log–rank test showed that muscle invasive bladder cancer patients with high CBX8 expression had a poor rate of overall survival (P < 0.001) and 5‐year recurrence‐free survival (P < 0.001) compared to patients with low CBX8 expression. High CBX8 expression predicted poor overall survival and 5‐year recurrence‐free survival in T and N stages of muscle invasive bladder cancer patients. Moreover, knockdown of CBX8 inhibited cell proliferation of urothelial carcinoma of the bladder both in vitro and in vivo. In addition, CBX8 depletion resulted in cell cycle delay of urothelial carcinoma cells of the bladder at the G2/M phase by the p53 pathway. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.

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Section: Resultsmentioning

confidence: 98%

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confidence: 99%

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confidence: 99%

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Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

et al. 2017

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“…Proliferation, invasion and cloning ability of ESCC cells (KYSE2 and KYSE510) were suppressed by silencing CBX8 [40]. Tang et al [41]. found that CBX8 was highly expressed in colorectal cancer tissue, suggesting a poor prognosis and that knockdown of CBX8 would increase the expression of p53 and its downstream effect factors, which would restrain the proliferation of colorectal cancer cells.…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Liu

Wang

Long

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) play a significant role in the development and progression of various human cancers. However, the expression and function of circRNAs in cervical cancer (CC) have rarely been explored. The aim of this study was to investigate the biological function of circRNA8924 in CC and elucidate the possible molecular mechanism involved. Methods: Quantitative polymerase chain reaction was used to determine mRNA expression of circRNA8924, miR-518d-5p/519-5p and CBX8 in CC tissues and cells. CBX8 protein expression was measured by Western blotting. The CCK-8 assay was used to evaluate cell proliferation, and the transwell assay to determine cell migration and invasion. The luciferase reporter assay was used to determine the direct regulation of miR-518d-5p/519-5p and circRNA8924 or CBX8 Results: The study demonstrated that the expression level of circRNA8924 in CC was significantly higher than that in the adjacent normal tissues (P < 0.001), and that it was also associated with tumor size, FIGO staging and myometrial invasion. The knockdown of circRNA8924 significantly inhibited the proliferation, migration and invasion of CC cells SiHa and HeLa. The expression level of miR-518d-5p/519-5p was negatively correlated with circRNA8924, and circRNA8924 regulated CBX8 by competitively binding to miR-518d-5p/519-5p. Conclusions: CircRNA8924 is highly expressed in CC tissue and can be considered a competitive endogenous RNA of the miR-518d-5p/519-5p family to promote the malignant biological behavior of CC cells. It is suggested that it may serve as a new biomarker for CC diagnosis and disease progression and provide potential targets for targeted therapy.

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“…In contrast, low levels of CBX7 mRNA correlate with disease progression and a negative prognosis in bladder carcinoma, while the loss of CBX7 protein expression correlates with a highly malignant phenotype in thyroid cancer, indicating that CBX7 regulates genes involved in cancer progression. Low levels of CBX8 are associated with a poor prognosis and high rate of distant metastasis in colorectal cancer patients . MEL18, the PRC1 subunit, exhibits tumor suppressor activity through inhibition of BMI1 expression .…”

Section: Pcgs Proteins As Diagnostic and Prognostic Biomarkers For Camentioning

confidence: 99%

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

Wang

Qin

Voruganti

et al. 2015

Medicinal Research Reviews

105

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Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More recently, they have been found to play important roles in human carcinogenesis and cancer development and progression. The deregulation and dysfunction of PcG proteins often lead to blocking or inappropriate activation of developmental pathways, enhancing cellular proliferation, inhibiting apoptosis, and increasing the cancer stem cell population. Genetic and molecular investigations of PcG proteins have long been focused on their PcG functions. However, PcG proteins have recently been shown to exert non-polycomb functions, contributing to the regulation of diverse cellular functions. We and others have demonstrated that PcG proteins regulate the expression and function of several oncogenes and tumor suppressor genes in a PcG-independent manner, and PcG proteins are associated with the survival of patients with cancer. In this review, we summarize the recent advances in the research on PcG proteins, including both the polycomb-repressive and non-polycomb functions. We specifically focus on the mechanisms by which PcG proteins play roles in cancer initiation, development, and progression. Finally, we discuss the potential value of PcG proteins as molecular biomarkers for the diagnosis and prognosis of cancer, and as molecular targets for cancer therapy.

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Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer

Cited by 51 publications

References 47 publications

Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

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