Global sensitivity analysis, like variance-based methods for massive raster datasets, is especially computationally costly and memory-intensive, limiting its applicability for commodity cluster computing. The computational effort depends mainly on the number of model runs, the spatial, spectral, and temporal resolutions, the number of criterion maps, and the model complexity. The current Spatially-Explicit Uncertainty and Sensitivity Analysis (SEUSA) approach employs a cluster-based parallel and distributed Python–Dask solution for large-scale spatial problems, which validates and quantifies the robustness of spatial model solutions. This paper presents the design of a framework to perform SEUSA as a Service in a cloud-based environment scalable to very large raster datasets and applicable to various domains, such as landscape assessment, site selection, risk assessment, and land-use management. It incorporates an automated Kubernetes service for container virtualization, comprising a set of microservices to perform SEUSA as a Service. Implementing the proposed framework will contribute to a more robust assessment of spatial multi-criteria decision-making applications, facilitating a broader access to SEUSA by the research community and, consequently, leading to higher quality decision analysis.