Parallel auditory pathways: projection patterns of the different neuronal populations in the dorsal and ventral cochlear nuclei

Cant, Nell B.; Benson, Christina G.

doi:10.1016/s0361-9230(03)00050-9

Cited by 327 publications

(308 citation statements)

References 254 publications

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“…In the cochlear nuclei of the Math1 (Atoh1) mutant mouse, most of the ventral cochlear nuclei and some unidentified cells in the dorsal cochlear nucleus are absent (Wang et al, 2005). The result in zebrafish suggests that the development of neurons projecting to the inferior colliculus (Cant and Benson, 2003), a mammalian homolog of the TS (Butler and Hodos, 1996), might also be impaired in the Math1 mutant mouse.…”

Section: Discussionmentioning

confidence: 99%

“…Although various classes of neurons have been identified within this complex region in adult vertebrate animals (Knudsen, 1977;McCormick, 1989;New et al, 1996;Cant and Benson, 2003), little is known about their embryological origins. Recent studies performed in mice showed that the auditory-related nuclei, that is, the cochlear nuclei, originate from a part of the lower rhombic lip, the dorsal-most portion of the hindbrain proliferative neuroepithelium, characterized by the expression of Wnt1 and/or Math1 (Atoh1; Wang et al, 2005;Farago et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Each type of sensory information enters adjacent but nonoverlapping regions of the dorsal hindbrain by means of the eighth nerve or the lateral line nerves (Piotrowski and Northcutt, 1996;Raible and Kruse, 2000). Various classes of interneurons have been described in this complex but phylogenetically conserved structure, based on their morphologies, connectivity, and physiological properties in adult animals from fish to mammals (Knudsen, 1977;McCormick, 1989;New et al, 1996;Cant and Benson, 2003). However, the embryological origins and molecular profiles of these interneurons remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Sassa

Aizawa

Okamoto

2007

Developmental Dynamics

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The dorsal hindbrain includes distinct classes of neurons for processing various sensory stimuli, but the developmental aspects of these neurons remain largely unknown. We identify here two distinct classes of neurons in the dorsal hindbrain of developing zebrafish: (1) neurons that express the inhibitory neuronal marker Gad1/2, and (2) neurons that express the zn-5 antigen and Lhx2/9 and require the basic helix-loop-helix transcription factor Atoh1a for development. Neurons were traced to their axon terminals by expressing green fluorescent protein using the Gal4VP16-UAS (UAS, upstream activating sequences) system in combination with the promoter/enhancer regions of gad2 for the Gad1/2(؉) neurons and zic1 for the zn-5(؉)Lhx2/9(؉) neurons. The Gad1/2(؉) neurons projected to the contralateral hindbrain, while the zn-5(؉)Lhx2/9(؉) neurons projected to the contralateral midbrain torus semicircularis, suggesting a role in auditory and lateral line sensory processing. Comparison of these projections with those from the cochlear nuclei to the inferior colliculus in mammals suggests similarities across vertebrate species. Developmental Dynamics 236:706 -718, 2007.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Sassa

Aizawa

Okamoto

2007

Developmental Dynamics

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“…The cochlear nucleus receives input from the spiral (cochlear) ganglion, which integrates auditory signals received by the cochlear hair cells in the Organ of Corti. Axons from the cochlear nucleus neurons travel through the trapezoid body and lateral lemniscus to auditory processing centers including the superior olivary nucleus, the nucleus of the trapezoid body, and the inferior colliculus (Cant and Benson, 2003). Therefore, RGCs and cochlear nucleus neurons are functionally similar in that they are projection neurons for the visual and auditory sense organs, respectively.…”

Section: Non-retinal Expression Of Math5-gfpmentioning

confidence: 99%

Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes

Hufnagel

Riesenberg

Saul

et al. 2007

Molecular and Cellular Neuroscience

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Retinal ganglion cell genesis requires the proneural bHLH transcription factor Math5 (Atoh7), but little is known about the regulatory elements that control its expression. Here, we investigate Math5 gene regulation using transgenic mice. These mice express GFP in the prenatal retina, livelabeling RGC axon migration and innervation of the brain. Unexpectedly, these Math5-GFP transgenes are also found in Math1 expression domains throughout the nervous system, intriguing since Math5 and Math1 normally exhibit nonoverlapping expression. Furthermore, Math5-GFP and Math1 are regulated similarly, by both Pax6 and Math1 itself, in the lower rhombic lip and dorsal spinal cord. We also show that Pax6 binds to particular Math5 and Math1 regulatory sequences in vitro. Together these data suggest that these atonal semi-orthologues may share conserved regulatory elements that are normally silent in the Math5 gene.

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“…An intriguing feature of these onset-PSTH types is that each cell type displaying such responses either appears to be inhibitory or to excite an inhibitory postsynaptic neuron (see review : Cant and Benson, 2003). OnC's are hypothesized to provide glycinergic wideband-inhibitory inputs to the DCN and PVCN, and project to the contralateral CN (Smith et al, 2005(Smith et al, , 1989Arnott et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Response patterns to sound associated with labeled globular/bushy cells in cat

Rhode

2008

Neuroscience

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The mammalian cochlear nucleus (CN) consists of a diverse set of neurons both physiologically and morphologically that are involved in processing different aspects of the sound signal. One class of CN neurons that is located near the entrance of the auditory nerve (AN) to the CN has an oval soma with an eccentric nucleus and a short-bushy dendritic tree and is called a globular/bushy cell (GBC). They contact the principal cells of the medial nucleus of the trapezoid body (MNTB) with the very large calyx of Held that is one of the most secure synapses in the brain. Because MNTB cells provide an inhibitory input to the lateral superior olive, a structure purported to play a role in lateralizing high frequency sounds, GBC physiology is of great interest. Results were obtained with intracellular recording and subsequent labeling with neurobiotin of 32 GBCs along with a number of cells characterized extracellularly as likely GBCs in the cochlear nucleus (CN) of cat. Their poststimulus discharge response pattern to repeated tones varies from a primarylike pattern, i.e., similar to the AN, to a primarylike pattern with a 0.5 to 2 ms notch after the initial spike, to an onset pattern with a lowsustained rate. They can represent low frequency tones and amplitude modulated signals exceptionally well with a temporal code.

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Parallel auditory pathways: projection patterns of the different neuronal populations in the dorsal and ventral cochlear nuclei

Cited by 327 publications

References 254 publications

Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes

Response patterns to sound associated with labeled globular/bushy cells in cat

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