Paramagnetic Ions as Relaxation Probes in Biological Systems

Burton, Dennis R.

doi:10.1007/978-94-009-9524-6_7

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Burton, D. R. [57] has studied the structure and function of immunoglobulin G and reported some of the interesting applications of NMR to study this molecule. An antibody is a regarding the side chain groups such as Glu, Asp, Lys, Arg, Met, Thr, Leu and others act as intrinsic non-disturbing probes of their local electronic microenvironment in a protein.…”

Section: Discussionmentioning

confidence: 99%

Nuclear Magnetic Resonance Spectroscopic Studies of Human Immunoglobulin ‘G’ in Alzheimer’s Disease

Mittal

Chaudhary²

2014

JBEMi

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In the present paper, we have studied human IgG in Alzheimer's disease(AD) using nuclear magnetic resonance spectroscopy. A comparison with normal controls is also made. NMR spectroscopy is a powerful tool to detect the chemical groups of amino acids in serum. According to data available with the present study we are giving some of the findings related to AD patients. A group Aspartic acid (α-CH) is found in four cases only of AD patients and this group was absent in all the normal healthy persons. The group isoleucine (δ-CH 3) has been found in all the blood samples of normal persons and AD patients. Glutamic acid (α-CH) is found in two cases of AD patients and was absent in all the normal persons and other patients of AD. Alanine (β-CH) is found in two cases of normal healthy people and four cases of AD patients only. Asparatic acid (α-CH) is found in four cases of AD patients only and absent in all the normal healthy people. Lysine (γ-CH 2) is found in one case of AD patient only and absent in all the normal healthy controls along AD patients. Isoleuicine (γ− CH 3) has been found in three cases of AD patients only and four normal healthy people. Cystine (α-CH) and Cystine (β-CH) have been found in two cases of AD patients only and absent in all the normals with AD patients. Tryptophane (α-CH) is found in two sample of AD patient only and absent in all the cases of AD and normal healthy people. The appearance or disappearance of NMR groups may be changes in the CNS due to alteration in trace elements and immunity Keywords : Chemical shift () δ , gyromagnetic ratio () γ , Nuclear Magnetic Resonance (NMR), Immunoglobulin G (IgG) and Alzheimer's disease (AD)

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Section: Discussionmentioning

confidence: 99%