Paramagnetic, pH and temperature-sensitive polymeric particles for anticancer drug delivery and brain tumor magnetic resonance imaging

Abstract

Smart polymer-based theranostic agents often exist the problem of low drug release rate and are difficult to reach the site of brain tumors for magnetic resonance imaging (MRI). To synthesize a theranostic agent for brain tumor MRI with high drug release rate, a paramagnetic, pH and temperature-sensitive polymeric particle (PPP) is synthesized using simplified processes in this work. These dually sensitive polymeric particles show negligible cytotoxicity against HeLa and glioma (C6) cells. The obtained polymeric particles can effectively load anticancer drug doxorubicin (DOX). In vitro drug release measurements exhibit retarded release profile when subjected to varying pH or temperature. Moreover, DOX-loaded PPP exhibits obvious antitumor properties for C6 cells. The percentage of cumulative DOX release is higher than 95 % while both pH and temperature are changed. The T 1 -weighted relaxivity values at 3 T are 12.41 mM -1 s -1 (pH = 6.3) and 10.75 mM -1 s -1 (pH = 7.4). In vivo MRI reveals that the PPPs can be effectively imaged in brain tumor (glioma).These results indicate that the PPPs have great potential in diagnosing and treating glioma.

Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy

“…The peaks at 815, 768, and 696 cm –1 can be ascribed to flexural vibration of C–H in benzene ring. Compared with the Figure a, b, the weak absorption peak at 450 cm –1 is derived from Gd–O vibration in Gd­(AA) 3 Phen . All these observations support the monomers have been successfully participated in the polymerization reaction.…”

“…The synthesis of NaUA and Gd­(AA) 3 Phen were according to our previous paper . CuS@copolymer composite microspheres with a core–shell structure were prepared via one-pot emulsifier-free emulsion polymerization.…”

“…The synthesis of NaUA and Gd-(AA) 3 Phen were according to our previous paper. 43 CuS@copolymer composite microspheres with a core−shell structure were prepared via one-pot emulsifier-free emulsion polymerization. Briefly, 0.5 g of hydrophilic CuS fluid, 0.6 g of St, 1.0 g of NIPAm, 0.25 g of MAA, and 0.12 g of KPS were dissolved in 50 mL of deionized water by ultrasound dispersion in an ice bath for 20 min.…”

Design and Synthesis of a Lead Sulfide Based Nanotheranostic Agent for Computer Tomography/Magnetic Resonance Dual-Mode-Bioimaging-Guided Photothermal Therapy

“…Our groups have recently developed a novel agent for brain tumor (glioma) MR imaging (MRI) that could be used as a good MRI contrast agent with high-relaxation-rate MRI . This agent can be used as a functional monomer to participate in polymer polymerization.…”

Nanocarriers Call the Last Shot in the Treatment of Brain Cancers

“… 130 Furthermore, external stimuli such as light, heat, and magnetic fields are other options for controlled release. Liu et al 276 have obtained physicochemical sensitive (pH, temperature, etc) nanopolymers with both anticancer effects and brain tumor magnetic resonance imaging. Their application for both diagnosis and treatment procedures has been positively approved.…”