In (k, r)-Center we are given a (possibly edge-weighted) graph and are asked to select at most k vertices (centers), so that all other vertices are at distance at most r from a center. In this paper we provide a number of tight fine-grained bounds on the complexity of this problem with respect to various standard graph parameters. Specifically:• For any r ≥ 1, we show an algorithm that solves the problem in O * ((3r + 1) cw ) time, where cw is the clique-width of the input graph, as well as a tight SETH lower bound matching this algorithm's performance. As a corollary, for r = 1, this closes the gap that previously existed on the complexity of Dominating Set parameterized by cw.• We strengthen previously known FPT lower bounds, by showing that (k, r)-Center is W[1]-hard parameterized by the input graph's vertex cover (if edge weights are allowed), or feedback vertex set, even if k is an additional parameter. Our reductions imply tight ETH-based lower bounds. Finally, we devise an algorithm parameterized by vertex cover for unweighted graphs.• We show that the complexity of the problem parameterized by tree-depth is 2 Θ(td 2 ) , by showing an algorithm of this complexity and a tight ETH-based lower bound.We complement these mostly negative results by providing FPT approximation schemes parameterized by clique-width or treewidth, which work efficiently independently of the values of k, r. In particular, we give algorithms which, for any > 0, run in time O * ((tw/ ) O(tw) ), O * ((cw/ ) O(cw) ) and return a (k, (1 + )r)-center if a (k, r)-center exists, thus circumventing the problem's W-hardness.