Parametric Rietveld refinement and magnetic characterization of superparamagnetic iron oxide nanoparticles

Pereira, Guilherme Ferreira Lemos; Costa, Fanny N.; Souza, J. A.; Haddad, Paula S.; Ferreira, Fábio Furlan

doi:10.1016/j.jmmm.2018.02.020

Cited by 17 publications

(6 citation statements)

References 54 publications

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“…ZFC and FC (in Figure 3c,d) therefore confirmed the superparamagnetic behavior of the material as T B values were found to be ∼216 and ∼225 K at 1000 and 500 Oersted, respectively. The shape of the FC and ZFC curves was indicative of the smaller particle size and narrower size distribution 35 for SPIONs, which is in agreement with TEM and AFM data. Next, we examined the optical properties of the SPIONs.…”

Section: ■ Results and Discussionsupporting

confidence: 86%

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Yadav

Rao

Kaushik

et al. 2022

ACS Appl. Nano Mater.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have become benchmark materials for their large magnetic saturation and excellent T2 contrast. Despite the large magnetic saturation that arises due to the enormous iron content, incorporating a fluorescent nature for their use as multimodal probes drastically reduces the magnetic saturation. To achieve the desired magnetic saturation in fluorescence-decorated SPIONs, the size is increased substantially to hundreds of nanometers. Here, we rationally design fluorescent SPIONs of size ∼16 nm with significant magnetic saturation and high single-particle photon counts used for optical-based super-resolution microscopy. The SPIONs were highly specific to stain and image the lysosomes of HeLa cells with high contrast and were capable of providing super-resolution radial fluctuation (SRRF) imaging of lysosomes down to 130 nm, which is much lower than the diffraction limit in light microscopy.

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Section: ■ Results and Discussionsupporting

confidence: 86%

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Yadav

Rao

Kaushik

et al. 2022

ACS Appl. Nano Mater.

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“…36 According to this, lower the T B value lower will be the volume, T B *50 K again confirms the smaller size of the material. The shape of the ZFC and FC curves were indicative of the smaller particle size and narrower size distribution for SPIONs 37 which is in accordance with TEM data. Hence, it could be concluded that the material has enough magnetic properties to be used as MRI contrasting agent.…”

Section: Resultssupporting

confidence: 86%

Magnetofluorescent Nanoprobe for Multimodal and Multicolor Bioimaging

et al. 2020

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Although, superparamagnetic iron oxide nanoparticles (SPIONs) have extensively been used as a contrasting agent for magnetic resonance imaging (MRI), the lack of intrinsic fluorescence restricted their application as a multimodal probe, especially in combination with light microscopy. In Addition, the bigger size of the particle renders them incompetent for bioimaging of small organelles. Herein, we report, not only the synthesis of ultrasmall carbon containing magneto-fluorescent SPIONs with size ∼5 nm, but also demonstrate its capability as a multicolor imaging probe. Using MCF-7 and HeLa cell lines, we show that the SPIONs can provide high contrast mulicolor images of the cytoplasm from blue to red region. Further, single particle level photon count data revealed that the SPIONs could efficaciously be utilized in localization based super resolution microscopy in future.

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“…The magnetization saturation (MS) values commonly found in the literature for magnetic nanoparticles are usually smaller than those for the corresponding bulk phases, which are ∼90 emu g –1 . ,, The lower magnetization value for the nanocomposites confirms the incorporation of SPIONs (10 and 30 wt %) into silica. Nanoparticles are attracted by a magnetic field, and when this field is removed, their magnetization is reduced close to zero, without residual magnetization. ,, The as-prepared nanoparticles, SPIONT, have a lower magnetic moment than SPIONCo, while in nanocomposites (Figure ), the magnetic moment does not vary in compounds with the same morphology. Besides avoiding the agglomeration of nanoparticles, this suggests that SBA-15 has mesopores that organize them so that the magnetization of nanoparticles obtained by coprecipitation and thermal decomposition is the same.…”

Section: Resultsmentioning

confidence: 99%

“…Nanoparticles are attracted by a magnetic field, and when this field is removed, their magnetization is reduced close to zero, without residual magnetization. 6,55,56 The as-prepared nanoparticles, SPIONT, have a lower magnetic moment than SPIONCo, while in nanocomposites (Figure 7), the magnetic moment does not vary in compounds with the same morphology. Besides avoiding the agglomeration of nanoparticles, this suggests that SBA-15 has mesopores that organize them so that the magnetization of nanoparticles obtained by coprecipitation and thermal decomposition is the same.…”

Section: N 2 Adsorption/desorption Isotherms (Nai)mentioning

confidence: 99%

Mesoporous Silica–Fe₃O₄ Nanoparticle Composites as Potential Drug Carriers

Losito

Araújo

Bezzon

et al. 2021

ACS Appl. Nano Mater.

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This work is an innovative study of ordered mesoporous silica (SBA-15) nanocomposites, with different morphologies, and superparamagnetic iron oxide nanoparticles (SPIONs), as promising drug delivery vehicles guided by magnetization. Incorporating SPIONs into SBA-15 is of great interest because it can improve controlled delivery of drugs as well as avoid agglomeration of the nanoparticles. SPIONs were prepared by coprecipitation and thermal decomposition methods and incorporated into SBA-15, with different morphologies, by the incipient wetness impregnation method. The nanocomposites (SBA-15:SPIONs) were characterized by physicochemical techniques, including small-angle X-ray scattering, X-ray diffraction, nitrogen adsorption−desorption isotherms, scanning and transmission electron microscopies, energy-dispersive spectroscopy, magnetization measurements, pair distribution function analysis, Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential thermal analysis. The X-ray diffraction and small-angle X-ray scattering data of the nanocomposites verified that the crystalline phase of magnetite (Fe 3 O 4 ) and the pore structure of the SBA-15 did not undergo significant changes. N 2 physisorption data evidenced significant changes in the textural properties of the pure SBA-15, indicating the incorporation of SPIONs into the mesopores, with greater incorporation when the nanoparticles are obtained by thermal decomposition, in agreement with the small-angle X-ray scattering results. Transmission electron microscopy images, energy-dispersive spectroscopy, and thermogravimetry results evidence the successful incorporation of SPIONs into the silica matrix. The SBA-15:SPIONs presented superparamagnetic behavior. The pair distribution function method revealed a significant variation in the local structure related to changes in the Si−Si−O coordination caused by the decrease in the SBA-15 particle size. The incorporation of SPIONs was better for silica with smaller particle sizes and a higher proportion of SPIONs. Biological assays, such as myelotoxicity and cell viability, demonstrated that the nanocomposites could be safe potential drug delivery vehicles.

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Parametric Rietveld refinement and magnetic characterization of superparamagnetic iron oxide nanoparticles

Cited by 17 publications

References 54 publications

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Magnetofluorescent Nanoprobe for Multimodal and Multicolor Bioimaging

Mesoporous Silica–Fe₃O₄ Nanoparticle Composites as Potential Drug Carriers

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Parametric Rietveld refinement and magnetic characterization of superparamagnetic iron oxide nanoparticles

Cited by 17 publications

References 54 publications

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Superparamagnetic Iron Oxide Nanoparticles with Large Magnetic Saturation and High Particle Photon Counts for Super-Resolution Imaging of Lysosomes

Magnetofluorescent Nanoprobe for Multimodal and Multicolor Bioimaging

Mesoporous Silica–Fe3O4 Nanoparticle Composites as Potential Drug Carriers

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Mesoporous Silica–Fe₃O₄ Nanoparticle Composites as Potential Drug Carriers