The first principles of things will never be adequately known.Science is an openended endeavor, it can never be closed. We do science without knowing the first principles. It does in fact not start from first principles, nor from the end principles, but from the middle. We not only change theories, but also the concepts and entities themselves, and what questions to ask. The foundations of science must be continuously examined and modified; it will always be full of mysteries and surprises." {1}