Parametric studies of matched filters to enhance the signal-to-noise ratios of LC–MS–MS peaks

Diagnostic application of the exponentially modified Gaussian model for peak quality and quantitation in high-throughput liquid chromatography–tandem mass spectrometry

“…One early model, the exponentially modified Gaussian (EMG) [14] has remained in the forefront of chromatographic peak fitting due to its handling of asymmetry, easily derived statistical moments, and robust handling of overlapped peaks. In addition to extensive application in GC and LC methods [15][16][17][18][19][20], the EMG has been shown to improve quantitation in areas as diverse as solid phase extraction [21], two dimensional GC [22], and metabolomics [23].…”