Paraneoplastic anti-CV2 antibodies react with peripheral nerve and are associated with a mixed axonal and demyelinating peripheral neuropathy

Antoine, Jean‐Christophe; Honnorat, Jérôme; Camdessanché, Jean‐Philippe; Magistris, Michel R.; Absi, Léna; Mosnier, Jean‐François; Petiot, P.; Kopp, Nicolas; Michel, D

doi:10.1002/1531-8249(20010201)49:2<214::aid-ana41>3.0.co;2-w

Cited by 160 publications

(63 citation statements)

References 27 publications

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“…On the other hand, muscle weakness, rather than sensory impairment, was the primary feature in our case. Paraneoplastic neuropathy with anti-CV2/CRMP-5 antibodies can develop into demyelinating neuropathy with slow progression (16). However, findings of CIDP without anti-CV2/CRMP-5 antibodies have also been reported in association with solid tumors (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Demyelinating Neuropathy and Autoimmune Hemolytic Anemia in a Patient with Pancreatic Cancer

Koike

Yoshida²,

Ito³

et al. 2013

Intern. Med.

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We herein report the case of a patient with pancreatic cancer who manifested features of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and autoimmune hemolytic anemia (AIHA). A 78-year-old Japanese man presented with AIHA and was treated with steroids and splenectomy. Although the AIHA improved following splenectomy, the patient suffered from sensorimotor neuropathy soon after undergoing surgery. The electrophysiological features indicated demyelinating neuropathy. The neuropathy was refractory to immunomodulatory treatment, and intensive investigations revealed pancreatic cancer. The patient's neurological deficits improved significantly after the surgery for cancer. Although the combination of AIHA and CIDP has been reported anecdotally, this is the first case of the coexistence of these diseases as paraneoplastic syndromes.

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Section: Discussionmentioning

confidence: 99%

Demyelinating Neuropathy and Autoimmune Hemolytic Anemia in a Patient with Pancreatic Cancer

Koike

Yoshida²,

Ito³

et al. 2013

Intern. Med.

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“…The absence of anti-Hu antibodies does not rule out an underlying cancer. Anti-CRMP5/CV2 antibodies also occur with paraneoplastic peripheral neuropathies [79]. These patients usually have a sensory or sensorimotor neuropathy, with less frequent involvement of the arms but often associated with cerebellar ataxia [16,79,80].…”

Section: Antineuronal Antibodiesmentioning

confidence: 99%

Managing Paraneoplastic Neurological Disorders

2006

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“…In connection with malignant disease (especially small-cell lung carcinoma, breast and ovarian cancer) [7] and Sjögren disease [61,105,112] the neuropathy is considered an autoimmune manifestation, and the nerve tissue is infiltrated by mononuclear cells [42]. Nevertheless, in some cases no underlying disease can be found.…”

Section: Etiologymentioning

confidence: 99%

Diagnosis of acute neuropathies

Crone

Krarup

2007

J Neurol

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Acute and subacute polyneuropathies present diagnostic challenges since many require prompt initiation of treatment in order to limit axonal degeneration and since an exact and detailed diagnosis is a prerequisite for making the correct choice of treatment. It is for instance of utmost importance to recognize whether the underlying pathological changes are due to demyelination or to axonal degeneration and electrodiagnostic tests can thus in most cases contribute considerably to the securing of an exact diagnosis. The specific and characteristic electrophysiological findings in the different types of acute and subacute neuropathies are discussed, and the various electrophysiological pitfalls and technical problems, which are met in these patients, are mentioned.

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Paraneoplastic anti-CV2 antibodies react with peripheral nerve and are associated with a mixed axonal and demyelinating peripheral neuropathy

Cited by 160 publications

References 27 publications

Demyelinating Neuropathy and Autoimmune Hemolytic Anemia in a Patient with Pancreatic Cancer

Demyelinating Neuropathy and Autoimmune Hemolytic Anemia in a Patient with Pancreatic Cancer

Managing Paraneoplastic Neurological Disorders

Diagnosis of acute neuropathies

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