Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

Abstract

Background Paraneoplastic cerebellar degeneration is usually associated with gynecological and breast cancer, lung cancer, and Hodgkin’s lymphoma. Renal cell carcinoma has rarely been described as an underlying malignancy in these cases. Case presentation We report the case of a 75 year-old woman who develop cerebellar ataxia following a respiratory viral infection. During investigation, around 1 year afterward, she noticed constitutional symptoms suggestive of malignancy. Renal carcinoma was found and the hypothesis of paraneoplastic cerebellar degeneration was considered. Conclusions As no specific antineuronal antibodies have been described in the setting of renal cell carcinoma, paraneoplastic cerebellar degeneration should be considered when the tumor is detected and other causes are excluded. Immunotherapy should be prescribed as soon as possible.

Paraneoplastički neurološki sindrom uz karcinom bubrega

“…Most neurologic PNS present as peripheral nervous system syndromes and myopathies, as shown in Table 1. Reports on central nervous system presentation are limited to anti-NMDAR and other limbic encephalitis, thus we present the first case of PNS associated with RCC which presented as severe form of Bickerstafflike brainstem encephalitis [2,[9][10][11][12][13][14][15] . Both conditions are antibody-mediated diseases treated with pulse dose methylprednisolone and TPE, which lead to temporal clinical response, as seen in our case.…”

Unusual Neurologic Paraneoplastic Syndrome in a Patient with Clear Cell Renal Cell Carcinoma

“…3 There are rare case reports of paraneoplastic syndromes secondary to renal cell carcinoma with neurologic presentations including opsoclonus-myoclonus, frontal lobe disorders, cerebellar degeneration, bilateral phrenic nerve paralysis, and amyotrophic lateral sclerosis, and motor weakness associated with sensory deficits. [4][5][6][7][8][9] Interestingly, a report published in 1963 describes a 48-year-old man who sought medical care after developing pain in his lower extremities, polyneuritis that progressed to motor weakness in the face and legs, paresthesias, and painful extremities that largely resolved following resection of a renal cell carcinoma. 10 To our knowledge, this is the only other reported case Written consent has been obtained from the patient with respect to all details included in the following submission.…”