Paraneoplastic opsoclonus‐myoclonus associated with anti‐Hu antibody

Hersh, Bradley S.; Dalmau, Josep; Dangond, Fernando; Gultekin, Sakir H.; Geller, Evan; Wen, Pao-Ying

doi:10.1212/wnl.44.9.1754

Cited by 57 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adult patients with breast cancer, POM is usually associated with anti-Ri antibodies [10,18]. Anti-Hu antibodies have been also reported in rare patients with POM and lung carcinoma [13]. We report a patient with POM, carcinoma of the pancreas, and a novel anti-Purkinje cell antibody, suggesting that in POM, autoimmune responses can be directed against different antigens.…”

mentioning

confidence: 74%

Paraneoplastic opsomyoclonus, cerebellar ataxia and encephalopathy associated with anti-Purkinje cell antibodies

Honnorat¹,

Trillet²,

Antoine³

et al. 1997

Journal of Neurology

View full text Add to dashboard Cite

mentioning

confidence: 74%

Paraneoplastic opsomyoclonus, cerebellar ataxia and encephalopathy associated with anti-Purkinje cell antibodies

Honnorat¹,

Trillet²,

Antoine³

et al. 1997

Journal of Neurology

View full text Add to dashboard Cite

“…Autoantibodies against Hu antigens underlie a multifocal neurological disease, paraneoplastic sensory neuropathy. The frequency of this PNS in SCLC patients with high titers of anti-Hu and corresponding PNS is only 1% (17). However, SCLC patients with low titers of anti-Hu and without PNS have also been found.…”

Section: Discussionmentioning

confidence: 97%

Autoantibodies against the Ca2+-binding protein recoverin in blood sera of patients with various oncological diseases

Savchenko¹,

Goncharskaia²,

Skorikova³

et al. 2011

Oncology Letters

View full text Add to dashboard Cite

Abstract. In cancer, the retinal Ca 2+ -binding protein recoverin is a paraneoplastic antigen, the aberrant expression of which is capable of triggering the appearance of specific autoantibodies in the serum of patients with malignant tumors and the subsequent development of a paraneoplastic syndrome, cancer-associated retinopathy (CAR). The frequency of serum autoantibodies against recoverin (AAR), earlier determined at a rate of 15-20% in lung cancer, is much higher than the frequency of CAR syndrome, which is approximately 1%. In the present study, we estimated for the first time the frequencies of serum AAR in patients with various types of malignancies other than lung cancer. Patient biospecimens were collected to analyze for the presence of AAR. Additionally, various cell lines were cultivated and analyses were performed using Western blotting and RT-PCR. Results showed that in all cases tested, the AAR frequencies did not exceed 10%. Five AAR-positive patients with various types of cancer were available for ophthalmological investigation and only one of these patients had CAR syndrome. This result is consistent with the conclusion made in our previous studies of lung cancer that serum AAR do not necessarily trigger the development of CAR syndrome. IntroductionNeuronal proteins, which are usually present only within the nervous system but may also be expressed in malignant tumors localized outside the nervous system, are assigned to paraneoplastic (onconeural) antigens (PNA). The immune system of certain patients responds to PNA by producing specific autoantibodies and/or cytotoxic T-cells that trigger the development of a paraneoplastic neurological syndrome (PNS) (1). One such PNA is the photoreceptor Ca 2+ -binding protein recoverin (2,3), which is normally specific to the retina and the pineal gland but may also be aberrantly expressed in malignant tumors of the lung and other tissues (4,5). In certain patients with lung cancer, high-titer serum autoantibodies against recoverin (AAR) trigger the development of a PNS, cancer-associated retinopathy (CAR) (6,7). However, low-titer serum AAR of patients with lung cancer do not necessarily cause CAR syndrome (8-10). Instead, this syndrome only occurs in approximately 1% of cancer patients, whereas the frequencies of serum AAR in patients with small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) equal 15 and 20%, respectively (10).By analogy with cancer-testis antigens, recoverin has been classified as a cancer-retina antigen (5) for the following reasons: i) its normal expression is restricted to an immunoprivileged tissue (retina), ii) it is aberrantly expressed in tumor cells, iii) it subsequently demonstrates high antigenicity (autoantibodies and/or T-cells), and iv) aberrant demethylation of the gene promoter is involved in the aberrant expression of recoverin (11).In this study, we analyzed serial specimens of blood sera of patients with a number of different malignancies to estimate the frequency of serum AAR in oncological disea...

show abstract

“…Todos os casos foram publicados no período de 1982 a 1989, não sendo descrita realização de pesquisa para anticorpos anti-neuronais. Por outro lado, encontramos relatos na literatura de associação de opsoclono-mioclono com presença de anticorpos anti-Hu e sintomas cerebelares em casos de carcinoma de ovário 13 e pulmão 14,15 . Hunter e Kooistra descreveram em 1986 os achados neuropatológicos em um caso idiopático de síndrome opsoclonomioclono 16 , considerados pelos autores bastante similares aos observados na DCPS: com depleção grave das células de Purkinje em todo o neo e paleo-cerebelo.…”

Section: Discussionunclassified

Degeneração cerebelar subaguda paraneoplásica: relato de caso

Bardy¹,

Cagy²,

Filho³

et al. 2000

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

RESUMO -Descrevemos caso de uma paciente de 40 anos com quadro de degeneração cerebelar subaguda paraneoplásica associada a tumor ovariano. Apresentamos breve revisão sobre as manifestações clínicas e laboratoriais desta síndrome, enfatizando a importância do seu reconhecimento, o que possibilita muitas vezes a detecção e tratamento precoce da doença primária.PALAVRAS-CHAVE: síndromes paraneoplásicas, degeneração cerebelar subaguda, câncer de ovário. Paraneoplastic subacute cerebellar degeneration: case reportABSTRACT -We report a 40-year-old woman with subacute cerebellar degeneration associated with ovarian cancer. We briefly review the clinical and laboratory features of this syndrome, and emphasize the importance of its prompt recognition, which many times makes possible the early detection and treatment of the primary disorder.KEY WORDS: paraneoplastic syndromes, subacute cerebellar degeneration, ovarian cancer.Complicações neurológicas atingem cerca de 50% dos pacientes com câncer durante o curso da doença. As neoplasias originadas fora do sistema nervoso podem afetar suas porções central e periférica de duas maneiras: 1) mecanismos diretos (invasão direta ou metástases); 2) mecanismos indiretos (obstrução vascular, déficit nutricional ou metabólico, efeitos tóxicos do tratamento, síndromes paraneoplásicas).Síndromes paraneoplásicas são doenças neurológicas com fisiopatologia relacionada ao câncer, mas não atribuíveis a metástases ou outros mecanismos indiretos citados acima. São as complicações mais raras nos pacientes com câncer, e sua freqüência é desconhecida. Podem afetar qualquer nível do sistema nervoso e freqüentemente antecedem a detecção do tumor. Seu diagnóstico correto depende de alto grau de suspeição por parte do médico, além do conhecimento de suas manifestações clínicas e dos tumores tipicamente a elas associados. Por anteceder o diagnóstico da neoplasia, sua importância reside na oportunidade de identificar e tratar precocemente o tumor, que muitas vezes é pequeno e escapa à detecção mesmo após avaliações clínicas repetidas.Relata-se caso de uma paciente com adenocarcinoma de ovário diagnosticado durante avaliação de síndrome pancerebelar subaguda. Detecção relativamente precoce da neoplasia e tratamento curativo só foram possíveis pela identificação da síndrome paraneoplásica e reconhecimento das patologias a ela associadas, possibilitando atuação rápida e direcionada da equipe.

show abstract

Paraneoplastic opsoclonus‐myoclonus associated with anti‐Hu antibody

Cited by 57 publications

References 0 publications

Paraneoplastic opsomyoclonus, cerebellar ataxia and encephalopathy associated with anti-Purkinje cell antibodies

Paraneoplastic opsomyoclonus, cerebellar ataxia and encephalopathy associated with anti-Purkinje cell antibodies

Autoantibodies against the Ca2+-binding protein recoverin in blood sera of patients with various oncological diseases

Degeneração cerebelar subaguda paraneoplásica: relato de caso

Contact Info

Product

Resources

About