Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Mimicking Limbic Encephalitis

Abstract

To compare the features of paraneoplastic syndrome of inappropriate antidiuretic hormone with those of limbic encephalitis.

Paraneoplastic cerebellar degeneration and lambert‐eaton myasthenia in a patient with merkel cell carcinoma and voltage‐gated calcium channel antibodies

“…In our patient, the coexistence of both LEM and PCD illustrates the heterogeneity of PNS manifestations in MCC. Also, our case, together with those previously reported, supports the relative high frequency of VGCC‐related syndromes associated with this tumor, as found typically in SCLC . LEM is a classical antibody‐mediated neurological disorder, which is associated with antibodies to VGCC in >90% of patients .…”

“…1 MCC shares many neuroendocrine features with small cell lung carcinoma (SCLC), 2 the most frequent tumor associated with paraneoplastic neurological syndromes (PNS). However, PNS, in association with specific onconeural or neuronal surface antibodies are rarely reported in MCC, [2][3][4][5][6][7][8][9][10][11][12][13] as reviewed in Supplementary Table S1, which is available online.…”

Merkel cell carcinoma of the abdominal wall

“…[ 14 ] Ectopic Anti Diuretic Hormone secretion by a neuroendocrine tumor with MCC phenotype was recently reported. [ 15 ] Serum NSE may prove to be a useful tumor marker in MCC. [ 16 ]…”

Paraneoplastic secretion of antidiuretic hormone in Merkel cell carcinoma: A case report

“…PNS associated with MCC are poorly described. Only cerebellar degeneration, Lambert-Eaton myasthenic syndrome, and malignancy-associated hyponatremia have been shown to be associated [3][4][5]. Herein, we report for the first time an inappropriate secretion of antidiuretic hormone (SIADH) associated with MCC with an increased level of antidiuretic hormone in neoplastic tissue.An 86-year-old woman with a history of hypertension, diabetes, hypercholesterolemia, and hypothyroidism was admitted for syncope diagnosed with severe aortic stenosis.…”