Paraneoplastic syndromes in patients with head and neck cancer

Minotti, Americo M.; Kountakis, Stilianos E.; Stiernberg, Charles M.

doi:10.1016/0196-0709(94)90132-5

Cited by 9 publications

(8 citation statements)

References 42 publications

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“…Clinical signs of mild hypercalcemia include anorexia, constipation, abdominal pain, nausea and vomiting, thirst with polyuria, myalgias, weakness, fatigue, headaches, depression, and confusion. Hypercalcemia is a medical emergency [67]. Hypercalcemia associated with advanced malignancy portends a dismal prognosis.…”

Section: Hypercalcemiamentioning

confidence: 99%

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Paraneoplastic Syndromes Associated with Laryngeal Cancer

et al. 2019

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Objectives: Paraneoplastic syndromes occur rarely in association with laryngeal cancer. When present, the syndrome may be the first sign of the malignancy. The aim of the present study was to review and report on all published cases in the international literature. Methods: A search of PubMed was conducted for ''paraneoplastic syndromes in laryngeal cancer'' without any restrictions on language or publication year. The full texts of all relevant articles were reviewed and all cases of paraneoplastic syndromes associated with any type of laryngeal cancer were extracted and analyzed. Results: We identified 59 cases of paraneoplastic syndromes related to laryngeal cancer in the literature published from 1963 until recently. There were 46 squamous cell carcinomas and 10 neuroendocrine carcinomas. Twenty-two of the paraneoplastic syndromes involved the endocrine system, 21 were dermatologic or cutaneous, 8 neurologic, 5 osteoarticular or rheumatologic, 1 ocular, 1 muscular, and 1 hematologic. Treatment strategies included surgery, radiotherapy, chemotherapy, and often multimodal therapy, depending on the histology and stage of the laryngeal cancer. Conclusions: Because of their rarity, paraneoplastic syndromes associated with laryngeal cancer are difficult to diagnose. By presenting and systematically reviewing all published cases in the international literature, the present review may help clinicians to recognize them and to suspect the diagnosis of laryngeal cancer at an earlier stage than otherwise might be possible.

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Section: Hypercalcemiamentioning

confidence: 99%

“…Hypercalcemia associated with advanced malignancy portends a dismal prognosis. Hypercalcemia is managed by treatment of the cancer responsible for it [67].…”

Section: Hypercalcemiamentioning

confidence: 99%

Paraneoplastic Syndromes Associated with Laryngeal Cancer

et al. 2019

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“…Severe hypercalcemia is considered a medical emergency. 68 Hypercalcemia complicating malignant disease is a poor prognostic sign and correlates with advanced disease, but it is important to distinguish this from hypercalcemia due to other causes, ie, sarcoidosis, primary hyperparathyroidism, or thiazide therapy. Treatment of malignancy-induced hypercalcemia is primarily directed toward controlling the underlying cancer.…”

Section: Paraneoplastic Endocrine Syndromesmentioning

confidence: 99%

Paraneoplastic Syndromes in Patients with Laryngeal and Hypopharyngeal Cancers

Ferlito¹,

Rinaldo²

2000

Ann Otol Rhinol Laryngol

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Paraneoplastic syndromes are systemic, nonmetastatic manifestations associated with a variety of malignant neoplasms and occurring in a minority of cancer patients. Paraneoplastic syndromes in association with cancers of the larynx and hypopharynx are considered rare. The world literature is reviewed, dividing paraneoplastic syndromes into 4 main groups, ie, cutaneous (acanthosis nigricans, Bazex's syndrome, Bowen's disease, bullous pemphigoid, dermatomyositis, pruritus, Sweet's syndrome, yellow nail syndrome, and tylosis), endocrine (carcinoid syndrome, adrenocorticotropic hormone syndrome, Schwartz-Bartter syndrome, hypercalcemia), hematologic (Trousseau's syndrome), and neurologic (cerebellar degeneration, Eaton-Lambert myasthenic syndrome). A paraneoplastic syndrome may precede the clinical manifestations of a persistent or recurrent tumor or of asymptomatic metastases, and its onset may even, in a minority of cases, be the presenting sign of a malignancy. Otolaryngologists and head and neck surgeons should have a knowledge of the paraneoplastic syndromes in order to facilitate their detection of malignancies or recurrences.

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“…Mostly the mechanisms of PNS are not well known, but ectopic hormone production is probably the most common mechanism [3]. Different studies have tried to identify specifi c antibodies associated with neurological disorders as a part of PNS.…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Neurological Syndrome with Demyelinating Polyradiculoneuropathy in Tonsil Cancer patient

Simunjak¹,

Filipovic²,

Pirkl³

et al. 2019

Arch Otolaryngol Rhinold

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Objective:To describe a rare case of a paraneoplastic neurological syndrome associated with tonsillar squamous cell carcinoma.Design: Case report. Patient:A 51-year-old female patient with paraneoplastic neurological disorder characterized by rapid and progressive bilateral facial paresis, diplopia, arm and leg weakness and paresthesia.Interventions: Symptomatic therapy for pain, surgery and radiotherapy for cancer. Main outcome measures:Medical fi le, radiological imaging, EMNG, immunological fi ndings and surgical report. Results:Patient neurological status drastically improved in early postoperative period (after primary surgical intervention). Only mild right facial paresis persisted upon release from hospital. Patient is scheduled for radiotherapy.Conclusion: This is to our knowledge fi rst case of paraneoplastic neurogical syndrome with demyelinating polyradiculoneuropathy associated with tonsillar carcinoma. In a case of an early staged carcinoma, symptomatic therapy and surgery alleviated or slowed progression of symptoms.

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Paraneoplastic syndromes in patients with head and neck cancer

Cited by 9 publications

References 42 publications

Paraneoplastic Syndromes Associated with Laryngeal Cancer

Paraneoplastic Syndromes Associated with Laryngeal Cancer

Paraneoplastic Syndromes in Patients with Laryngeal and Hypopharyngeal Cancers

Paraneoplastic Neurological Syndrome with Demyelinating Polyradiculoneuropathy in Tonsil Cancer patient

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