Parapsoriasis and mycosis fungoides: The Northwestern University experience, 1970 to 1985

Lazar, Andrew; William, A.; Roenigk, Henry H.; Pinski, Kevin S.

doi:10.1016/s0190-9622(89)70277-2

Cited by 44 publications

(19 citation statements)

References 8 publications

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“…Immunostains with specific markers are needed for diagnosis in all such instances. [67] Chronic superficial dermatitis (small plaque parapsoriasis) shows banal, mild lymphocytic infiltrate in upper dermis with a parakeratotic epidermis. [68] Large plaque parapsoriasis shows a more pronounced dermal lymphocytic infiltrate, with mild epidermotropism of mononulcear cells.…”

Section: Ichthyosiform Diseasesmentioning

confidence: 99%

Invisible dermatoses

Mysore¹

2010

Indian J Dermatol Venereol Leprol

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'Invisible dermatoses' is a concept which has not received wide recognition, but is nevertheless very important both clinically and histologically. The term invisible dermatoses has been used in two contexts: a) Diseases, with out definite clinical features, and are therefore "invisible" to the clinician, but yet can be diagnosed by special investigations. b) Dermatoses which present with definite and obvious clinical features, but subtle or hidden histological features and are therefore "invisible" histologically. Diagnosis of such diseases represents a great challenge to both the dermatologist and dermatopathologist. This article discusses such diseases and offers clues and tools for their diagnosis. Diagnosis of such 'Invisible dermatoses' needs proper awareness, recognition of subtle features, special stains, special investigations such as immunofluorescence and histochemistry and proper clinicopathological correlation.

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Section: Ichthyosiform Diseasesmentioning

confidence: 99%

Invisible dermatoses

Mysore¹

2010

Indian J Dermatol Venereol Leprol

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“…Of note, the data on the progression rates to MF in PSEP are conflicting, ranging from 0% to 45%. 18,19 It is worth noting that the hypopigmented presentation is known to occur in other lymphoproliferative diseases including the pityriasis lichenoides chronica 20,21 and MF 22 and it seems that the hypopigmented variants might be more common among dark-skinned patients, as the aforementioned presentation of hypopigmented pityriasis lichenoides chronica was reported in dark-skinned individuals. Also hypopigmented MF shows a higher prevalence among individuals with dark complexions.…”

Section: Discussionmentioning

confidence: 99%

Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: A report of 34 patients and a 7-year experience

El-Darouti

Fawzy

Hegazy

et al. 2012

Journal of the American Academy of Dermatology

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“…Additional studies will be needed to determine if flow cytometric differences exist between so-called parapsoriasis and MF, 2 conditions considered by some to be one and the same. 10,[74][75][76][77][78][79][80] One patient (case 19) whose biopsy histology was consistent with MF and was positive by both FC and TCRg-PCR had complete clinical resolution of her cutaneous lesions 3 months after discontinuing several drugs including a calcium channel blocker 81 ; however, long-term clinical follow-up was unavailable for this patient, who died of unrelated causes within 1 year of FC analysis, at age 94. Four patients (cases 1, 3, 4, and 5) subsequently developed clinical SzS, and in 3 of these patients, MF/SzS cells were identified in the blood or bone marrow by FC (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Flow Cytometric Evaluation of Skin Biopsies for Mycosis Fungoides

Jokinen

Fromm

Argényi

et al. 2011

The American Journal of Dermatopathology

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Multicolor flow cytometry (FC) is indispensable for lymphoma diagnosis and classification, but its utility in evaluating skin biopsies for mycosis fungoides (MF) is not well established. We describe the largest series to date of skin biopsies evaluated by FC for MF (n = 33), and we compare the flow cytometric results with the histologic, molecular, and clinical findings. Abnormal T-cell populations were identified by FC in 14 of 18 patients (78%) having histologically confirmed MF and in no patient whose histology was negative or indeterminate for MF (n = 14). One patient had histologic, flow cytometric, and molecular findings compatible with MF, but this patient's clinical course was more suggestive of a drug eruption. Fourteen of 15 abnormal T-cell populations showed definitive aberrant expression of at least 2 surface antigens, including CD2 (47%), CD3 (67%), CD4, CD5 (87%), CD7, and CD45 (67%); most cases (67%) had light scatter properties suggesting increased cell size and/or cytoplasmic complexity. The high specificity of FC suggests that it will be a useful adjunct to routine histology in the evaluation of diagnostic skin biopsies for MF.

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Parapsoriasis and mycosis fungoides: The Northwestern University experience, 1970 to 1985

Cited by 44 publications

References 8 publications

Invisible dermatoses

Invisible dermatoses

Hypopigmented parapsoriasis en plaque, a new, overlooked member of the parapsoriasis family: A report of 34 patients and a 7-year experience

Flow Cytometric Evaluation of Skin Biopsies for Mycosis Fungoides

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