Paraquat-induced convulsion and death: a report of five cases

Huang, Changbao; Zhang, Xigang; Jiang, Yining; Li, Guang; Wang, Hao-Chun; Tang, Xueping; Wang, Qunli

doi:10.1177/0748233712442712

Cited by 13 publications

(7 citation statements)

References 12 publications

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“…Moreover, paraquat is a contact dihydropyridine herbicide which is extremely toxic to mammals, causing multiorgan failure and finally death (32). Paraquat has been reported to cause brain damage via formation of oxygen-free radicals (60), leading to neuronal cell death that finally causes disease.…”

Section: Discussionmentioning

confidence: 99%

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

Singh

Chhunchha

Fatma

et al. 2016

American Journal of Physiology-Cell Physiology

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Section: Discussionmentioning

confidence: 99%

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

Singh

Chhunchha

Fatma

et al. 2016

American Journal of Physiology-Cell Physiology

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“…Paraquat poisoning is characterized by multiple organ function failure, mainly involving the lung, kidney, heart, liver, and nervous system 16 . Yu et al observed that treatment with UA could protect neurons against excitotoxic and metabolic insults involving suppression of oxyradical accumulation, stabilization of calcium homeostasis, and preservation of mitochondrial function 17 .…”

mentioning

confidence: 99%

The significance of serum uric acid level in humans with acute paraquatpoisoning

Zhang

Zhao

Bai

et al. 2015

Sci Rep

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Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients with acute paraquat poisoning. A total of 205 subjects who had attempted suicide by oral ingestion of paraquat were admitted to the emergency room between January 2009 and June 2014. Initial serum UA level and other laboratory parameters were measured. A total of 66 patients died during the 30 days after admission, corresponding to a 32.2% cumulative incidence of mortality. UA levels were higher in non-survivors than survivors (P < 0.001) and 30-day mortality increased with increasing baseline serum UA level (P < 0.001). In a prediction analysis for 30-day mortality, the serum UA level had a cut-off concentration of 284 µmol/L in female patients and 352 µmol/L in male patients. Multivariate Cox proportional hazards regression analyses showed that white blood cell counts and UA were independent prognostic factors. In conclusion, we showed that serum UA may be an independent predictor of 30-day mortality in patients with paraquat poisoning.

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“…Viologen derivatives (4,4'-bipyridinium salts) were commonly used as non-selective herbicides (e.g. Paraquat) [18], but they can also cause severe or lethal poisoning in humans [19]. Interestingly, there are growing data indicating the association between chronic Paraquat exposure and Parkinson's disease [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line

Łaźniewska

Miłowska

Katir

et al. 2013

Cellular and Molecular Biology Letters

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Dendrimers containing viologen (derivatives of 4,4'-bipyridyl) units in their structure have been demonstrated to exhibit antiviral activity against human immunodeficiency virus (HIV-1). It has also recently been revealed that novel dendrimers with both viologen units and phosphorus groups in their structure show different antimicrobial, cytotoxic and hemotoxic properties, and have the ability to influence the activity of cholinesterases and to inhibit α-synuclein fibrillation. Since the influence of viologen-phosphorus structures on basic cellular processes had not been investigated, we examined the impact of such macromolecules on the murine neuroblastoma cell line (N2a). We selected three water-soluble viologen-phosphorus (VPD) dendrimers, which differ in their core structure, number of viologen units and number and type of surface groups, and analyzed several aspects of the cellular response. These included cell viability, generation of reactive oxygen species (ROS), alterations in mitochondrial activity, morphological modifications, and the induction of apoptosis and necrosis. The MTT assay results suggest that all of the tested dendrimers are only slightly cytotoxic. Although some changes in ROS formation and mitochondrial function were detected, the three compounds did not induce apoptosis or necrosis. In light of these results, we can assume that the tested VPD are relatively safe for mouse neuroblastoma cells. Although more research on their safety is needed, VPD seem to be promising nanoparticles for further biomedical investigation.

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Paraquat-induced convulsion and death: a report of five cases

Cited by 13 publications

References 12 publications

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

The significance of serum uric acid level in humans with acute paraquatpoisoning

Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line

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