Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: Report of a very rare case

Zozumi, Masataka; Nakai, Mayumi; Matsuda, Ikuo; Hao, Hiroyuki; Tsukamoto, Yoshitane; Shiraishi, Yusuke; Nojima, Masanori; Yamamoto, Shingo; Hirota, Seiichi

doi:10.1016/j.prp.2012.10.015

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…In comparison with well‐differentiated and dedifferentiated liposarcoma, it occurs in a younger age group and arises particularly in the lower extremities (thigh and popliteal area) and very rarely in the abdominal cavity and retroperitoneum. A molecular genetic profile is very helpful with the diagnosis, with the typical t(12;16)(q13.3;p11.2) and t(12;22)(q13.3;q12.2) translocations resulting in human FUS/DDiT3 being found in the majority of cases…”

Section: Fna Diagnostic Aspects Combined With Molecular Informationmentioning

confidence: 99%

“…In comparison with well-differentiated and dedifferentiated liposarcoma, it occurs in a younger age group and arises particularly in the lower extremities (thigh and popliteal area) and very rarely in the abdominal cavity and retroperitoneum. A molecular genetic profile is very helpful with the diagnosis, 33 with the typical t(12;16)(q13.3;p11.2) and t(12;22)(q13.3;q12.2) translocations resulting in human FUS/DDiT3 being found in the majority of cases. 34,35 Myxofibrosarcoma is constantly cytologically composed of isolated and regular clusters of wavy spindleshaped cells, round cells without a specific pattern, moderate cytonuclear atypia, and an abundant myxoid background as well as curvilinear vascular structures.…”

Section: Myxoid Tumorsmentioning

confidence: 99%

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Value of combined cytology and molecular information in the diagnosis of soft tissue tumors

Klijanienko

Sastre-Garau²,

Theocharis³

2014

Cancer Cytopathology

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The diagnosis of a soft tissue tumor (STT) is a complex process that requires a multidisciplinary team consisting of a medical oncologist, a radiologist, a pathologist, and a molecular biologist. The combination of this information gives highly accurate results. Fine‐needle aspiration in this setting is one of the most performed techniques for obtaining, in a noninvasive way, optimal material for morphological, immunohistochemical, and molecular purposes. On the other hand, an accurate tumor diagnosis is a dynamic process, as evidenced by the constant modifications of international putative classifications, which are more and more based on molecular aberrations (2013 World Health Organization classification). In the future, STT classification will certainly be a hybrid of morphology and molecular data and, consequently, will be very “useful” for cytology. Cancer (Cancer Cytopathol) 2015;123:141–151. © 2014 American Cancer Society.

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Section: Fna Diagnostic Aspects Combined With Molecular Informationmentioning

confidence: 99%

Section: Myxoid Tumorsmentioning

confidence: 99%