Parathyroid Carcinoma: Etiology, Diagnosis, and Treatment

Okamoto, Takahiro; Iihara, Masatoshi; Obara, Takao; Tsukada, Toshihiko

doi:10.1007/s00268-009-9999-0

Cited by 56 publications

(48 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The best treatment for parathyroid carcinoma is early total extirpation of the tumor and circumjacent tissues [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Surgeons should perform en bloc resection (ipsilateral thyroid lobe, adjacent musculature, paratracheal lymphatic tissue [Level VI] and, if involved, the thymus), as this has much influence on the prognosis and the rate of local recurrence [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Nevertheless, this is a tumor with a high rate of local recurrence and successful cure after relapse is rare.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, he had a history of gastric ulcer. There was no family history of primary hyperparathyovoid, with a brown color and yellowish undertones [3][4][5][6][7][12][13][14][15][16][17][18].…”

Section: Case Reportmentioning

confidence: 99%

“…However, metastases to bone, pleura, pericardium and pancreas have been reported. In cases of recurrent disease, it is advisable to perform a neck and chest CT scan and sestamibi scintigraphy [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Case Reportmentioning

confidence: 99%

See 2 more Smart Citations

Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

et al. 2013

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

et al. 2013

View full text Add to dashboard Cite

“…In 1973 Schantz and Castleman proposed the criteria that may be helpful to diagnose cancer. They contain: increased mitotic activity, thick fibrous bands, trabecular growth pattern, and capsular and blood vessels invasion (present in over 60% of cases) [15,18,45]. Unfortunately, none of these criteria are specific only for parathyroid carcinoma; they can also be observed in benign parathyroid lesions and are not always present in cases of malignancy [5,6,18].…”

Section: Histopathological Examinationmentioning

confidence: 99%

“…Besides these features, multi-nodular surface, solid consistency, and infiltration of surrounding tissues (ipsilateral thyroid lobe, cervical muscles, vessels, lymph nodes) may help in the differential diagnosis [16,54,55]. Invasion normally affects the thyroid gland (15%) and regional lymph nodes (4%) [21,45,[50][51][52][53][54][55][56]. In contrast to carcinoma, parathyroid adenoma tends to be smaller, soft, and ovoid with a brown colour and yellowish undertones [6,20] (Table I).…”

Section: Prace Poglądowementioning

confidence: 99%

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Dabrowska

Tarach

Zwolak

2015

Endokrynologia Polska

View full text Add to dashboard Cite

Parathyroid carcinoma (PC) is a rare endocrine malignancy and the cause of primary hyperparathyroidism. It is usually associated with a high rate of local and distant recurrence. Laboratory findings and clinical symptoms may be similar to those in parathyroid adenoma. The histological features of PC may also be non-specific and the affected gland is often indistinguishable from a benign lesion. The proper diagnosis is commonly made months to years later when the disease recurs or metastases are present. Therefore, parathyroid carcinoma still remains a diagnostic and management challenge for many physicians. However, there are some features that, in combination, may help in diagnosis. Surgery still remains the only curative treatment, even in metastatic disease. In advanced, non-operable subjects, managing hypercalcaemia and controlling a tumour are the main goals. Morbidity is caused by hypercalcaemia rather than metastases. A multidisciplinary approach with experienced endocrinologists, pathologists, radiologists, nuclear medicine doctors, oncologists, and surgeons is needed to optimize patient outcome. StreszczenieRak przytarczyc (PC) jest rzadkim nowotworem złośliwym układu wewnątrzwydzielniczego, a także rzadką przyczyną pierwotnej nadczynności przytarczyc. Zazwyczaj wiąże się z wysokim odsetkiem miejscowych i odległych przerzutów. Wyniki badań laboratoryjnych i objawy kliniczne mogą przypominać te spotykane w przebiegu gruczolaków przytarczyc. Równie niespecyficzny jest obraz histopatologiczny raka przytarczyc, co powoduje trudności w diagnostyce różnicowej ze zmianami łagodnymi, będącymi gruczolakami. Właściwe rozpoznanie często jest stawiane z kilkumiesięcznym lub kilkuletnim opóźnieniem, w oparciu o nawrót choroby lub pojawiające się przerzuty. Mając na uwadze ten fakt, rak przytarczyc ciągle pozostaje wyzwaniem diagnostycznym i terapeutycznym dla wielu specjalistów. Jakkolwiek, wyróżnia się jednak pewne objawy, których obecność może pomóc w postawieniu właściwej diagnozy. Leczenie chirurgiczne pozostaje nadal jedyną skuteczną opcją terapeutyczną, nawet w sytuacji pojawienia się zmian przerzutowych. W zaawansowanych, nieoperacyjnych przypadkach głównym celem leczenia pozostaje obniżanie stężenia wapnia we krwi i kontrola wielkości guza. Śmiertelność związana z rakiem przytarczyc wynika raczej z hiperkalcemii, niż obecności przerzutów. W celu poprawy wyników leczenia, niezbędne jest podejście wielodyscyplinarne oraz współdziałanie wielu doświadczonych specjalistów: endokrynologów, patologów, radiologów, medyków nuklearnych, onkologów i chirurgów.

show abstract

Parathyroid carcinoma: A review

et al. 2011

View full text Add to dashboard Cite

Background. Parathyroid carcinoma is a rare entity, comprising fewer than 1% of cases of hyperparathyroidism. The disease generally presents with severe hyperparathyroidism and occasionally with vocal cord paralysis or a firm palpable cervical mass.Methods. The classic histopathologic features of trabecular pattern, mitotic figures, thick fibrous bands, and capsular and vascular invasion are not present in every case but are useful in assessing whether a particular hyperfunctional parathyroid lesion is a carcinoma. Nevertheless, recognition of malignancy at initial operation may be difficult. Management primarily involves complete surgical removal through en bloc resection, which may include adjacent central neck structures.Results. Adjuvant radiation therapy has not been proven to be uniformly effective, but several series show results suggestive of a possible survival advantage. Chemotherapy, genetic, and other biomodifying agents remain experimental. Long-term outcome for this neoplasm remains problematic, and complications from intractable hypercalcemia constitute the foremost cause of death. Reported 5-year survivals have ranged between 70% and 85%.Conclusions. Initial surgical success offers the greatest opportunity for cure. Reoperation for recurrence offers the potential for short-and intermediate-term relief from the sequelae of hypercalcemia, but rarely results in cure. Severely elevated calcium levels should be controlled before initial surgery, and much of the treatment for recurrent or persistent disease, including reoperative surgery, is directed at control of hypercalcemia.

show abstract

Parathyroid Carcinoma: Etiology, Diagnosis, and Treatment

Abstract: To establish valid evidence for patient management in the future, a collaboration of endocrine specialists is essential to conduct well-designed clinical studies for this rare disease.

Cited by 56 publications

References 94 publications

Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

Parathyroid carcinoma and oxyphil parathyroid adenoma: an uncommon case of misinterpretation in clinical practice

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Parathyroid carcinoma: A review

Contact Info

Product

Resources

About