Parathyroid hormone (1‐34) compensates the negative effect of smoking around implants

Lima, Liana Linhares; Neto, João Batista César; Cayana, Ezymar Gomes; Nociti, Francisco Humberto; Sallum, Enílson Antônio; Casati, Márcio Zaffalon

doi:10.1111/j.1600-0501.2012.02502.x

Cited by 17 publications

(14 citation statements)

References 33 publications

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“…Most of the studies investigating the impact of PTH (1-34) on bone healing around titanium implants evaluated its effect in animals with conditions that lead to systemic bone loss e.g. osteoporosis (19), aging (12) and smoking (20). The present study investigated young normoreactive rats and demonstrated that PTH (1-34) is able not only to compensate the negative effects of bone catabolic conditions (e.g.…”

Section: Discussionmentioning

confidence: 72%

Effect of Different Doses of Synthetic Parathyroid Hormone (1-34) on Bone around Implants: a Preclinical Rat Model

et al. 2019

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The aim of this study was to evaluate the effect of a lower dose of parathyroid hormone- PTH (1-34) on osteogenic potential of bone healing around titanium implants inserted into the tibia of rats. A blind parallel study was conducted in 45 adult male Wistar rats. Each rat received one titanium implant (4.5 x 2.2 mm) and was randomly assigned to receive subcutaneous injections, three times/week for 30 days, of the following treatments: group 1 - 40 µg/kg of PTH (1-34) (n=15); group 2 - 2 µg/kg of PTH (1-34) (n=15) and; group 3 - only the vehicle required for hormone dissolution (n=15). Thirty days after surgery, the animals were sacrificed and specimens containing the implant and the surrounding bone were removed and processed for non-decalcified sections. The sections were evaluated according to the following histometric parameters: proportion of mineralized tissue (PMT) adjacent to the implant threads (500 µm band); bone filling within the limits of the threads (BF) and; bone-to-implant contact (BIC). For the cortical region, both hormone dosages (groups 1 and 2) promoted better results, for all parameters, when compared to control group (p<0.05). Similar results were observed for the BF parameter in the cancellous region (p=0.0394). Therefore, systemic administration of PTH (1-34) stimulates bone formation around titanium implants, even at low doses.

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Section: Discussionmentioning

confidence: 72%

Effect of Different Doses of Synthetic Parathyroid Hormone (1-34) on Bone around Implants: a Preclinical Rat Model

et al. 2019

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“…Previous studies documented that the use of adjunctive agents (e.g growth factors, hormones and vitamins) in addition to the bone graft used, can enhance the graft properties and lead to successful regenerative results improving implant to bone contact (Qi et al 2004;Lima et al 2013;Xu et al 2015). Active vitamin D3 plays a significant role in homeostasis of bone minerals and can act as a biologically active protein enhancing osteogenesis (Li et al 1998;Lips 2006;Stoffels et al 2006).…”

Section: Xenogenic Bone Grafts Have Been Widely Used In Different Alvmentioning

confidence: 99%

Vitamin D3 in Alveolar Bone Augmentation Performed Simultaneously with Dental Implant placement. A Controlled Clinical and Radiographic Study

Amr

2019

Egyptian Dental Journal

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Section: Introductionmentioning

confidence: 99%

“…Consequently, implant modifications and systemic agents have been tested in smoking conditions, although none has been described as a potential and/or safe mediator of bone metabolism in this at‐risk circumstance (Chrcanovic et al, ; Lima et al, ). Lima et al () investigated the effect of Recombinant Human Parathyroid Hormone (PTH 1–34) on attenuating the influence of cigarette smoking on bone around titanium implants in rats and suggested that this agent increased bone volume around implants. However, the PTH (1–34) side effects as hypercalcemia and increased incidence of osteosarcoma (Jolette et al, ; Vahle et al, ) require that a protocol for the use of this substance in implant therapy should be established, if possible including short‐term period and low doses of PTH (1–34).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol reverses the negative effect of smoking on peri‐implant repair in the tibia of rats

Ribeiro

Pimentel

Corrêa

et al. 2018

Clinical Oral Implants Res

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Objectives Innovative approaches capable to improve peri‐implant bone repair are relevant in the presence of smoking, a risk factor for healing around implants. This study investigated the effect of resveratrol (RESV) on peri‐implant repair, and its influence on bone‐related markers in rats submitted to cigarette smoking inhalation (CSI). Materials and methods One titanium implant was inserted in each tibiae of rats assigned to CSI+RESV (n:18); CSI+placebo (n:18); and non‐CSI (n:18). One implant was removed for counter torque, and the peri‐implant tissue was collected for mRNA quantification of BMP‐2, OPN, Runx2, Lrp‐5, Osx, β‐catenin, Dkk1, OPG, and RANKL. The other tibia was submitted to microCT to measure: bone volume, bone porosity, trabecular spacing, trabecular thickness, and bone‐implant contact (BIC). Results No differences were detected between counter torque in CSI+RESV and non‐CSI group (p > 0.05), whereas CSI+placebo group presented lower values when compared to the others (p < 0.05). RESV improved the BIC in CSI rats without differences when compared to non‐CSI group (p > 0.05), whereas CSI+placebo showed reduced BIC when compared to the other groups (p < 0.05). RESV reduced RANKL/OPG and Lrp‐5 levels and increased β‐catenin in CSI rats when compared to CSI+placebo (p < 0.05). Conclusion Although further investigations should be considered using oral models of dental implants, within the limits of the present study, it was concluded that RESV reverses the negative effects of smoking in the peri‐implant repair, benefiting the modulation of bone‐related markers.

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Parathyroid hormone (1‐34) compensates the negative effect of smoking around implants

Abstract: In the presence of cigarette smoke, a factor related to poor bone healing and low bone density, PTH (1-34) increased bone volume around implants.

Cited by 17 publications

References 33 publications

Effect of Different Doses of Synthetic Parathyroid Hormone (1-34) on Bone around Implants: a Preclinical Rat Model

Effect of Different Doses of Synthetic Parathyroid Hormone (1-34) on Bone around Implants: a Preclinical Rat Model

Vitamin D3 in Alveolar Bone Augmentation Performed Simultaneously with Dental Implant placement. A Controlled Clinical and Radiographic Study

Resveratrol reverses the negative effect of smoking on peri‐implant repair in the tibia of rats

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