Parathyroid hormone 1–34 enhances titanium implant anchorage in low-density trabecular bone: A correlative micro-computed tomographic and biomechanical analysis

Intermittent Parathyroid Hormone Enhances Cancellous Osseointegration of a Novel Murine Tibial Implant

“…The finding that iPTH enhanced bone formation within our titanium implant is consistent with the beneficial effects of iPTH therapy on osseointegration seen in other models [17][18][19][20][21][22][23]35 . In our study, an increase in trabecular number, as opposed to trabecular thickness, appeared to be the primary structural change resulting from iPTH in the peri-implant region compared with the distal region.…”

“…In previous animal models, iPTH enhanced implant osseointegration of nonphysiologically loaded cortical and cancellous bone in rabbits and rats [17][18][19][20][21][22][23] . These models fail to simulate the intra-articular environment and physiologic loading that accompany tibial cancellous fixation in total knee arthroplasty.…”

“…Previous studies of in vivo models suggested that iPTH improves osseointegration [17][18][19][20][21][22][23][29][30][31][32][33][34] . Previous studies on osseointegration, however, had substantial limitations, including (1) use of large animals (rabbits, sheep, and dogs) with accompanying high cost, lower throughput 17,19,30,31,[35][36][37][38] , and greater humanitarian concerns compared with those related to small-animal models; (2) nonphysiologic implant placement such as in the medullary canal or extra-articular locations 18,[20][21][22]32,39 ; and (3) reliance on cortical bone support for stability 18,[20][21][22]40 . In the present study, we used a newly developed murine model with an intra-articular titanium implant that was loaded through the knee joint and supported by the cancellous bone bed of the proximal part of the tibia.…”

Avaliação tomográfica e tensiométrica de fêmures de ratas ooforectomizadas submetidas à terapia de reposição hormonal

“…A análise óssea pela tomografia computadorizada é primordial na comprovação dos efeitos de reabsorção e formação óssea (22)(23)(24) , além de caracterizar fielmente a arquitetura óssea, propiciando melhor compreensão da morfologia em ratos (25) . A tomografia tem a capacidade de estabelecer uma correlação entre as propriedades biomecânicas e a morfologia do osso, em fêmures de ratos (26,27) . Esse exame pode, ainda, refletir claramente os parâmetros das propriedades morfológicas do osso e ser utilizado em experimentos in vivo (28) .…”

Computational analyses of small endosseous implants in osteoporotic bone

“…As an alternative animal model for very small implants, the rat has successfully been used to test anchorage of implants in low density bone (Gabet et al, 2006).…”