Parathyroid Hormone, Electrolytes, and Blood Pressure

Vitamin D, Parathyroid Hormone, and Blood Pressure in the National Health and Nutrition Examination Surveys

“…The positive association between serum PTH and BP is consistent with previous studies. [8][9][10][11][12]14,16 The lack of an association between PTH and BP in a previous report from the 2003-2004 NHANES survey is probably due to the much smaller sample size (n = 1,654), restricted to people who were fasting, with reduced power to detect an association, compared with our analyses. 17 Previous cross-sectional studies, which measured both 25(OH)D and PTH, have not reported data on the association between 25(OH)D and BP adjusted for PTH, 14-17 possibly because mostly they observed no association between vitamin D and BP, even without adjusting for obesity (with waist circumference).…”

“…7 Elevated level of PTH has long been linked to hypertension. [8][9][10][11][12][13] However, only a few epidemiological studies of BP have examined both 25(OH)D and PTH together. Although a US prospective study has reported a significant inverse association between baseline 25(OH)D levels and subsequent risk of hypertension that is independent of PTH, 2 other studies, which have reported findings for both hormones, have generally found that BP is more strongly associated with PTH (positively) than with 25(OH)D (negatively); [14][15][16] suggesting that the effect of vitamin D on BP is indirect through to its suppression of serum PTH.…”