Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Hysaj, Ola; Marqués-Gallego, Patricia; Richard, Aline; Elgizouli, Magdeldin; Nieters, Alexandra; Lötscher, Katharina C. Quack; Rohrmann, Sabine

doi:10.3390/nu13020360

Cited by 10 publications

(16 citation statements)

References 62 publications

(96 reference statements)

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“…In our analysis, a significant impact of calcium and vitamin D intake on PTH concentration was not demonstrated. However, varying effects of dietary and supplemental calcium intake on PTH concentration are described previously [8,9]. The dietary or supplemental intake did not affect PTH among healthy, Caucasian pregnant women from Ireland [8].…”

Section: Discussionmentioning

confidence: 79%

“…postmenopausal women reported that calcium intake (1000mg/day) and vitamin D intake (1000IU/day) suppressed PTH significantly; still, neither calcium nor vitamin D supplements alone suppressed serum PTH [9]. The mixed results could be attributed to a lack of homogeneity and design errors.…”

Section: Plos Onementioning

confidence: 98%

“…Yet, the available evidence on the effects of supplemental calcium on PTH is controversial in the background of lack of consensus regarding the recommended intake of calcium during pregnancy [6][7][8]. Previous reports suggest other determinants such as socioeconomic and lifestyle factors might predict PTH levels in non-pregnant adults, but research among pregnant women is lacking [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid hormone in Sri Lankan pregnant women: Vitamin D and other determinants

et al. 2021

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Introduction Determinants of parathyroid hormone level during pregnancy have been less frequently studied. We aimed to describe the serum parathyroid hormone (PTH) and its determinants in Sri Lankan pregnant women in a community setting. Materials and methods In this cross-sectional analysis, 390 pregnant mothers in their third trimester were enrolled from primary care centers of 15 health divisions in the Colombo District in Sri Lanka. Venous blood was analyzed for a total 25-hydroxyvitamin-D [25(OH)D], serum parathyroid hormone (PTH), serum calcium, and alkaline phosphatase. The bone quality was assessed in terms of speed of sound (SOS) using the quantitative ultrasound scan (QUS). Univariate and multivariate regression analysis was used to examine the determinants of PTH concentration in blood. Results Median serum 25(OH)D was 17.5ng/mL. Most (61.6%) were vitamin D deficient (<20ng/mL). Median PTH was 23.7pg/mL. Only 0.8% had hyperparathyroidism (PTH >65pg/mL). The correlation between 25(OH)D and PTH was weak but significant (r = -0.197; p<0.001). SOS Z-score was below the cut-off (≤−2) in fifty-six women (14.7%), and SOS did not relate significantly to PTH. In regression analysis, serum 25(OH)D, serum calcium, body mass index, educational level, and weeks of pregnancy were significant independent variables when adjusted. The model explained 16% of the variation in the PTH level. Conclusions A high prevalence of vitamin D deficiency was observed among Sri Lankan pregnant women in the present study. Serum 25(OH)D, calcium, weeks of pregnancy, and educational level were determinants of serum PTH.

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Section: Discussionmentioning

confidence: 79%

Section: Plos Onementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Parathyroid hormone in Sri Lankan pregnant women: Vitamin D and other determinants

et al. 2021

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“…In addition, PTHrP produces the relaxation of the smooth muscles of the uterus and stimulates cell growth and differentiation. In humans, the concentration of PTHrP in the blood increases throughout pregnancy, and its levels correlate with the calcium concentration [ 31 , 32 ].…”

Section: Pthrp Adipose Tissue and Pregnancymentioning

confidence: 99%

The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue

Izquierdo‐Lahuerta

2021

Biomolecules

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Adipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions. Recent studies have shown how the parathyroid hormone-related protein (PTHrP)/Parathyroid Hormone Receptor 1 (PTH1R) axis participates in the regulation of adipogenesis, opposing the action of Peroxisome proliferator-activated receptor gamma (PPARγ). In addition to this, PTHrP is overexpressed in adipose tissue in situations of wear and tear of the body, favoring browning and lipolysis in this tissue. It is also overexpressed in adipose tissue in stressful situations but in the opposite direction, in obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). In conclusion, the PTHrP/PTH1R axis has a main role in adipose tissue, participating in its differentiation and remodeling. PTHrP might be used in obesity treatment and its complications for its ability to reprogram adipogenesis and adipose tissue expansion, WAT browning and for the improvement of the insulin sensitivity. In addition, PTHrP could even be used as a marker of placental status and maternal adaptations to prevent future metabolic problems in mothers and children, as well as in the treatment of bone-related diseases such as osteoporosis.

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“…Studies in normal pregnancies have demonstrated that median PTH serum concentrations are statistically lower in early pregnancy compared to late pregnancy, while PTH-rP and corrected calcium levels are significantly higher in pregnant women than in nonpregnant women [6,7]. Furthermore, it has been demonstrated that type 2 diabetics presented higher serum PTH-rP levels than control subjects, and PTH-rP induces insulin expression in pancreatic β-cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

PTH-rP and PTH-R1 Expression in Placentas from Pregnancies Complicated by Gestational Diabetes: New Insights into the Pathophysiology of Hyperglycemia in Pregnancy

et al. 2021

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Background: this study investigated the expression of parathyroid hormone-related protein (PTH-rP) and PTH/PTH-rP receptor PTH-R1 in placentas from women with gestational DM (GDM), and the relationship between PTH-R1 and PTH-rP expression and pregnancy characteristics. Methods: we prospectively enrolled 78 pregnant women with GDM, and immunochemistry for PTH-rP and PTH-R1 was performed on placentas. Patients were grouped according to the positivity of PTH-R1 or PTH-rP expression, and pregnancy characteristics were compared between the two groups. Results: PTH-rP and PTH-R1 expression were highest in the extravillous cytotrophoblast and in the decidua. In extravillous cytotrophoblast, PTH-rP expression was higher in women with abnormal at fasting glycemia compared to women with abnormal 60′ or 120′ glycemia (25/25, 50% vs. 6/28, 21.4%, χ2 = 6.12, p = 0.01), and PTH-R1 expression was higher in women with abnormal oral glucose tolerance test (OGTT) at fasting glycemia compared to women with abnormal 60′ or 120′ glycemia (37/50, 74% vs. 15/28, 53.6%, χ2 = 3.37, p = 0.06). In syncytiotrophoblast, PTH-rP-positive placentas were characterized by higher incidence of 1 min Apgar score < 7 (2/9, 22.2% vs. 2/69, 2.9%, χ2 = 6.11, p = 0.01) and maternal obesity (4/9, 44.4% vs. 11/69, 16.7%, χ2 = 3.81, p = 0.05). Conclusion: placental PTH-rP and PTH-R1 expression is dependent on the type of maternal hyperglycemia, and it is associated with adverse pregnancy outcomes.

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Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Cited by 10 publications

References 62 publications

Parathyroid hormone in Sri Lankan pregnant women: Vitamin D and other determinants

Parathyroid hormone in Sri Lankan pregnant women: Vitamin D and other determinants

The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue

PTH-rP and PTH-R1 Expression in Placentas from Pregnancies Complicated by Gestational Diabetes: New Insights into the Pathophysiology of Hyperglycemia in Pregnancy

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