Paraventricular nucleus activation of renal sympathetic neurones is synaptically depressed by nitric oxide and glycine acting at a spinal level

Yang, Zhuo; Smith, L.; Coote, John H.

doi:10.1016/j.neuroscience.2003.10.032

Cited by 10 publications

(11 citation statements)

References 35 publications

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“…These findings support the notion that NO plays an inhibitory role in the spinal cord, probably through its effects on SPNs. These results are in agreement with those obtained in anesthetized rats [9], which showed that intrathecal administration of L-arginine reduces MAP, HR [9], and renal sympathetic nerve activity [27]. The results of the current study are also in agreement with a previous in vitro study from immature rats that demonstrated that Larginine promotes an increase in the amplitude of inhibitory postsynaptic currents in SPNs, possibly through a cGMPdependent mechanism [25].…”

Section: Discussionsupporting

confidence: 93%

“…The enzyme nitric oxide synthase (NOS) is responsible for the synthesis of nitric oxide (NO) from L-arginine [10,17] and is sensitive to the calcium/calmodulin complex [1,27]. Neurotransmitters that activate receptors or ion channels and in turn lead to increases in intracellular Ca 2+ may also stimulate NOS and cause its release [27].…”

Section: Introductionmentioning

confidence: 99%

“…Neurotransmitters that activate receptors or ion channels and in turn lead to increases in intracellular Ca 2+ may also stimulate NOS and cause its release [27]. NOS is activated in the central nervous system (CNS) by glutamatergic activation of N-methyl-D-aspartate (NMDA) receptors, including those found on the sympathetic preganglionic neurons (SPNs) of the intermediolateral cell column (IML) of the spinal cord [3].…”

Section: Introductionmentioning

confidence: 99%

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Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate

Sabino

Bombarda

Silva

et al. 2010

Pflugers Arch - Eur J Physiol

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The modulatory effect of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway on sympathetic preganglionic neurons still deserves further investigation. The present study was designed to examine the role of the spinal cord NO/cGMP pathway in controlling mean arterial pressure and heart rate. We observed that intrathecal administration of the NO synthase inhibitor Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) causes an increase in mean arterial pressure but does not affect heart rate. Intrathecal administration of the soluble guanylyl cyclase inhibitor 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) does not change mean arterial pressure and heart rate. The precursor for NO synthesis, L-arginine, reduces both mean arterial pressure and heart rate while administration of ODQ before L-arginine impaired decreases in mean arterial pressure and heart rate. Administration of the N-methyl-D-aspartate (NMDA) receptor antagonist DL-2-amino-5-phosphonopentanoic acid (AP5) after L-NAME does not affect increases in mean arterial pressure promoted by NO synthase inhibition. Although the hypotensive and bradycardic responses induced by intrathecal administration of L-arginine depend on cGMP, our results indicate that NO acts to tonically inhibit SPNs, independent of either cGMP or NMDA receptors.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate

Sabino

Bombarda

Silva

et al. 2010

Pflugers Arch - Eur J Physiol

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“…The concentrations used were based on Yang et al (2004), Stafford and Coote (2006) and Stafford et al (2006a).…”

Section: Drugsmentioning

confidence: 99%

“…Physiological studies have shown that NO acts as a messenger molecule in spinal sympathetic networks where it may enhance post synaptic potentials via an action on the presynaptic transmitter release (Wu and Dun, 1995), or inhibit sympathetic neurones retrogradely via glycine interneurones (Wu and Dun, 1996;Yang et al, 2004). The actions appear to participate in sympathetic vasomotor regulation (Hakim et al, 1995;Lee at al., 1996;Garcia et al, 1997, Yang et al, 2004. However the distribution of NOS positive spinal autonomic neurones is extensive suggesting that NO may have important actions on other autonomic functions.…”

Section: Introductionmentioning

confidence: 99%

A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats

et al. 2007

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Variability in the occurrence of nitric oxide synthase immunoreactivity in different populations of rat sympathetic preganglionic neurons

Hinrichs

Llewellyn‐Smith

2009

J of Comparative Neurology

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The proportion of sympathetic preganglionic neurons (SPN) showing nitric oxide synthase (NOS) immunoreactivity appears to vary with innervation target and blood pressure level. For normotensive Sprague-Dawley rats (SD), we evaluated peroxidase immunolabelling for choline acetyltransferase (ChAT) plus NOS in spinal cord segments T1-L2 and assessed NOS immunofluorescence in SPN retrogradely labelled with cholera toxin B subunit from the adrenal medulla (AM) or superior cervical (SCG), coeliac (CG), or major pelvic (MPG) ganglia. We also compared the distributions and numbers of NOS-positive and NOS-negative/ChAT-positive lateral horn neurons in SD with those in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). In SD, WKY, and SHR, rostrocaudal, dorsoventral, and mediolateral differences occurred in the distributions of NOS-positive and NOS-negative/ChAT-positive neurons in the intermediolateral cell column (IML), whereas the two groups were similarly distributed throughout the central autonomic area (CAA). Among the four retrogradely labelled populations of SPN, the percentages showing NOS immunoreactivity differed (CG-projecting, 54.8% +/- 0.7%; SCG-projecting, 75.3% +/- 1.2%; MPG-projecting, 89% +/- 1.1% and AM-projecting, 98.6% +/- 0.2%). Within each retrogradely labelled group of SPN, the NOS-positive proportion also varied with subnuclear location (e.g., 25.5% +/- 4.0% of CG-projecting SPN in the CAA vs. 82.7% +/- 7.6% of CG-projecting SPN in the dorsolateral funiculus). The numbers of NOS-positive and NOS-negative/ChAT-positive neurons in T9-T11 were the same in SD and SHR but differed in WKY. Our results show that the expression of NOS within SPN varies depending on the target that they innervate and also on their subnuclear location. Our data indicate that there are no anatomical differences between nitric oxide-synthesizing SPN in normotensive SD and hypertensive SHR.

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Paraventricular nucleus activation of renal sympathetic neurones is synaptically depressed by nitric oxide and glycine acting at a spinal level

Cited by 10 publications

References 35 publications

Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate

Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate

A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats

Variability in the occurrence of nitric oxide synthase immunoreactivity in different populations of rat sympathetic preganglionic neurons

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