Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats

Gong, Ming; Chen, G.; Zhang, X. M.; Xu, Linhao; Wang, H. M.; Yan, Min

doi:10.1111/j.1399-6576.2012.02665.x

Cited by 24 publications

(19 citation statements)

References 33 publications

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“…Cognitive function is one of the most basic and important high-level neurological functions in the brain, and it is a basic indicator of the development of human intelligence. Supporting our result, many previous studies also reported the effect of sevoflurane, as well as other anesthetics, on cognitive function (Chen et al, 2001;Millar et al, 2006;Peng et al, 2011;Gong et al, 2012). Interestingly, Peng et al (2011) found that exposure to 1.5% sevoflurane, for as long as 3 d (2 h/d), did not cause significantly different cognitive performance, while exposure to 3% sevoflurane for 2 h was enough to induce cognitive impairment.…”

Section: Discussionsupporting

confidence: 89%

Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia

Ling

Ma²,

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Though sevoflurane has been widely used as an anesthetic in surgery, recent studies have shown that exposure to sevoflurane alone could lead to postoperative cognitive dysfunction (POCD), of which the mechanisms still remain largely unknown. The medial prefrontal cortex (mPFC) is known to be implicated in various cognitive impairments, including working memory and attentional processes. In the present study, we tried to identify dysregulated gene expression in mPFC and investigate the underlying mechanisms involved in POCD. Methods: Behavioral tests, including elevated plus-maze, O-maze, and Y-maze tests, were performed on Wistar rats exposed to sevoflurane. Whole-genome mRNA profiling of mPFC from Wistar rats after exposure to sevoflurane was carried out. Real-time polymerase chain reaction (PCR) was done to verify the differentially expressed genes. Results: Significant impairment of working memory of rats after exposure to sevoflurane was observed. A total of 119 of 7319 detected mRNAs showed significantly different expression between rats with and without sevoflurane exposure (fold change (FC)>2.0, P<0.05, and false discovery rate (FDR)<0.05), among which 74 mRNAs were down-regulated and 45 mRNAs were up-regulated. Postsynaptic density-95 (PSD95, also named DLG4) showed the most significantly decreased expression in mPFC and further investigation indicated that PSD95 expression level was correlated with spatial working memory performance. Conclusions: Our study revealed that PSD95 might be involved in the mechanism of POCD, which could provide clues for preventing POCD in clinical operations.

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Section: Discussionsupporting

confidence: 89%

Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia

Ling

Ma²,

et al. 2015

J. Zhejiang Univ. Sci. B

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“…Sevoflurane also increases levels of the pro-inflammatory cytokine interleukin-6 and tumor necrosis factor-α in the developing mouse brain (7). Anti-inflammatory therapy significantly attenuated the cognitive impairments induced by sevoflurane in young and aged rats (7,41). Our previous study demonstrated that isoflurane induces neuroapoptosis by activating the p38-NF-κB signaling pathway in the brain of developing rats (16).…”

Section: Discussionmentioning

confidence: 84%

Influence of sevoflurane exposure on mitogen-activated protein kinases and Akt/GSK-3β/CRMP-2 signaling pathways in the developing rat brain

Liu

Zeng

et al. 2017

Exp Ther Med

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Abstract. Prolonged exposure to volatile anesthetics causes neurodegeneration in developing animal brains. However, their underlying mechanisms of action remain unclear. The current study investigated the expression of proteins associated with the mitogen-activated protein kinases (MAPK) and protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β)/collapsin response mediator protein 2 (CRMP-2) signaling pathways in the cortices of neonatal mice following exposure to sevoflurane.

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“…However, the cognitive impairment induced by anaesthetics may depend on different factors, and it was recently shown that sevoflurane leads to increased interleukin-6 (IL-6) levels and induces neuroinflammation and cognitive disorders in young mice (18). In contrast, Gong et al (4) investigated the effects of a nonsteroid anti-inflammatory drug (parecoxib) on cognitive impairments and they concluded that parecoxib attenuated the nugatory effects induced by sevoflurane in rats. Dexamethasone, which is a widely used agent in the perioperative course to prevent postoperative nausea, vomiting, and inflammatory events, can inhibit the production of IL-6 (19).…”

Section: Discussionmentioning

confidence: 99%

“…The main reason for POCD is not clearly understood, but animal studies have shown that anaesthetic agents can play a role in causing neurodegenerative changes in the brain (3). The cognitive impairment effects of sevoflurane on both aged and young rats have been shown by several researchers, but there is a paucity of data on adult rats (4,5).…”

mentioning

confidence: 99%

Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats

Karaman

Doğru

et al. 2017

Turk J Anaesth Reanim

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Objective: Postoperative cognitive dysfunction (POCD) is common after anaesthesia in elderly patients. However, it may appear in patients of all ages. The main pathogenesis of cognitive dysfunction remains unclear, although there is some evidence that brain inflammation may alter cognitive abilities. In the present study, we aim to evaluate short-term and long-term effects of dexamethasone on cognitive dysfunction induced by sevoflurane anaesthesia in adult rats.Methods: Seven-month-old 30 male Wistar albino rats were randomised into three groups: sevoflurane group (exposure to sevoflurane), sevoflurane + dexamethasone group (exposure to sevoflurane and dexamethasone injection), and control group (exposure to 100% oxygen). Spatial learning and short-term (7 days after exposure) and long-term (30 days after exposure) memory were evaluated using Morris water maze test.Results: Sevoflurane induced significant deficit in spatial learning and short-term and long-term memory in adult rats. Dexamethasone-treated animals exposed to sevoflurane had equivalent performance as control animals in training and probe trials. Conclusion:Sevoflurane may impair spatial learning and short-term and long-term memories in adult rats. The co-administration of dexamethasone and sevoflurane may ameliorate short-term and long-term cognitive dysfunctions induced by sevoflurane in adult rats. Keywords: Sevoflurane, dexamethasone, cognitive disordersAmaç: Postoperatif kognitif disfonksiyon (POKD) yaşlı hastalarda anestezi sonrası sık olmaktadır. Ancak POKD tüm yaşlarda da görü-lebilmektedir. Kognitif disfonksiyonun temel patogenezi tam olarak bilinmemekle birlikte beyin inflamasyonunun bilişsel yetenekleri değiştirebildiğine dair bazı kanıtlar bulunmaktadır. Bu çalışmada, erişkin farelerde sevofluran anestezisi ile oluşturulmuş kognitif disfonksiyon üzerine deksametazonun erken ve geç dönem etkilerini araştırmayı amaçladık.Yöntemler: Yedi aylık 30 erkek wistar albino rat üç gruba ayrıldı; grup sevofluran (sevofluran anestezisine maruziyet), grup sevofluran+deksametazon (sevofluran anestezisiyle birlikte deksametazon enjeksiyonuna maruziyet) ve grup kontrol (%100 oksijene maruziyet). Uzaysal öğrenme, erken (maruziyetten 7 gün sonra) ve geç (maruziyetten 30 gün sonra) dönem hafıza Morris su labirenti testi ile değerlendirildi. Bulgular: Sevofluran anestezisi erişkin ratlarda uzaysal öğrenme, erken ve geç dönem hafıza üzerinde anlamlı derecede olumsuz etki oluşturdu. Deksametazon ile tedavi edilmiş ratlar ise eğitim ve araş-tırma testlerinde kontrol grubuna benzer bir performans gösterdi.Sonuç: Sevofluran erişkin ratlarda uzaysal öğrenmeyi, erken ve geç dönem hafızayı olumsuz etkileyebilir. Sevofluran anestezisi ile birlikte deksametazon uygulanması erişkin ratlarda sevofluran ile oluş-turulmuş erken ve geç dönem kognitif disfonksiyonu iyileştirebilir.Anahtar sözcükler: Sevofluran, deksametazon, biliş bozuklukları Abstract / Öz

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Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats

Abstract: Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats. The synaptic morphometry change may be one of the mechanisms involved in learning and memory deficit.

Cited by 24 publications

References 33 publications

Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia

Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia

Influence of sevoflurane exposure on mitogen-activated protein kinases and Akt/GSK-3β/CRMP-2 signaling pathways in the developing rat brain

Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats

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