Parental age and risk of epilepsy: A nationwide register‐based study

Dreier, Julie Werenberg; Petersen, Liselotte; Pedersen, Carsten Bøcker; Christensen, Jakob

doi:10.1111/epi.14453

Cited by 6 publications

(2 citation statements)

References 42 publications

(72 reference statements)

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“…Duration of marriage was defined as the difference in time (in years) between participation in the NFPHEP and registration of the marriage. The definition of age gap could vary according to previous studies ( 19 , 31 ). In this study, we calculated the age gap within couples and arbitrarily categorized them as follows: no age gap, wife older than husband, husband 1–2 years older, husband 3–5 years older, or husband ≥6 years older.…”

Section: Methodsmentioning

confidence: 99%

Couple-level determinants of syphilis infection among heterosexual married couples of reproductive age in Guangdong Province, China: A population-based cross-sectional study

Han

Xiong²,

Li³

et al. 2022

Front. Public Health

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BackgroundSyphilis remains a major public health problem worldwide, and its prevention requires knowledge of factors that go beyond the individual-level. However, most syphilis-related studies have focused on individual-level and regional-level factors, neglecting couple-level factors. Thus, this study aimed to explore couple-level determinants of syphilis infection among heterosexual married couples.MethodsThis population-based cross-sectional study used data from heterosexual married couples who participated in the National Free Preconception Health Examination Project in Guangdong Province, China during 2014–2019. The syphilis infection was tested by the rapid plasma reagin test. Couple-level data were obtained by combining information provided by the man and woman living in the same household. Multivariate logistic models were employed to explore the couple-level determinants of syphilis infection by gender after adjusting for potential confounders.ResultsA total of 1,755,156 couples were recruited in this analysis. The seroprevalence was 0.25% (95%CI: 0.24–0.25%) and 0.26% (95%CI: 0.25–0.27%) among men and women, respectively. The median age was 28.0 (interquartile range, IQR: 25.0–31.0) years, and the median duration of marriage was 0.2 (IQR: 0.0–2.5) years. After adjusting for individual and regional-level variables, duration of marriage was a protective factor for syphilis infection in men (adjusted odds ratios, AOR: 0.97; 95% CI: 0.96–0.98) and women (AOR: 0.95, 95% CI: 0.94–0.96). The age gap and the difference in education level between the husband and wife were associated with syphilis infection, but these associations were somewhat different between men and women. Condom use was negatively associated with syphilis infection in men (AOR: 0.77; 95% CI: 0.70–0.84) and women (AOR: 0.77, 95% CI: 0.71–0.84). Our results also showed that couple mobility and the number of children were not statistically significant determinants of syphilis infection among heterosexual married couples.ConclusionThis study contributes to a more comprehensive understanding of syphilis outcomes in individuals in the context of marriage in China. Several couple-level factors are indeed associated with syphilis infection, but these associations differ between men and women. Couple-based strategies that engage both women and men and efforts to promote condom use among heterosexual married couples need to be developed and further evaluated for syphilis prevention.

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Section: Methodsmentioning

confidence: 99%

Couple-level determinants of syphilis infection among heterosexual married couples of reproductive age in Guangdong Province, China: A population-based cross-sectional study

Han

Xiong²,

Li³

et al. 2022

Front. Public Health

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“…Additionally, demographic and clinical factors may also contribute to epilepsy risk in offspring. Parental age, for instance, has been implicated as a potential contributing factor, with advanced parental age possibly correlating with an elevated risk of epilepsy in their children [15]. Similarly, parental gender may influence the transmission of epilepsy, although the specifics of this relationship warrant further exploration [2,3].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Inheritance Risk: Epilepsy Prevalence among Offspring of Adults with Epilepsy in a Tertiary Referral Epilepsy Center

Intravooth,

Baran,

Wendling

et al. 2024

JCM

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While significant strides have been made in comprehending the pathophysiology and treatment of epilepsy, further investigation is warranted to elucidate the factors impacting its development and transmission, particularly within familial contexts. This study sought to explore the prevalence and risk factors associated with epilepsy in the offspring of patients with epilepsy who were treated at a tertiary epilepsy center. Adult patients with confirmed epilepsy (PWE) receiving outpatient care were consecutively enrolled, starting from January 2021 to January 2023. Data were recorded for various variables, including age, gender, epilepsy pathophysiology, cognitive impairment, and family history of epilepsy. Descriptive statistics, various statistical tests, and multivariate logistic regression analyses were employed to analyze the data. A total of 1456 PWE were included. Among them, 463 patients (31.8%) had children. Twenty-five patients had offspring diagnosed with epilepsy, representing a prevalence of 5.4%. Analysis of the offspring with epilepsy revealed older ages, a higher proportion of parents with idiopathic epilepsy, and a greater prevalence of a positive family history of epilepsy. Multivariate logistic regression analysis demonstrated a significant association between a family history of epilepsy and increased epilepsy risk in offspring. Genetic syndrome-immanent predisposition, advanced age, and a family history of epilepsy were identified as significant risk factors for epilepsy in offspring by means of this mono-center study.

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Effect of advanced parental age on pregnancy outcome and offspring health

Zhang

Yan

Qiao

2022

J Assist Reprod Genet

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Parental age and risk of epilepsy: A nationwide register‐based study

Abstract: Maternal age and parental age gap, but not paternal age, were associated with the offspring's risk of epilepsy. Our results do not support the hypothesis that de novo mutations associated with advanced paternal age increase the risk of epilepsy in the offspring.

Cited by 6 publications

References 42 publications

Couple-level determinants of syphilis infection among heterosexual married couples of reproductive age in Guangdong Province, China: A population-based cross-sectional study

Couple-level determinants of syphilis infection among heterosexual married couples of reproductive age in Guangdong Province, China: A population-based cross-sectional study

Evaluating the Inheritance Risk: Epilepsy Prevalence among Offspring of Adults with Epilepsy in a Tertiary Referral Epilepsy Center

Effect of advanced parental age on pregnancy outcome and offspring health

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