Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: A randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer

Torrinhas, Raquel Susana; Cruz, Raquel Santana da; Garcia, T K P; Cury-Boaventura, Maria Fernanda; Sales, Marcelo Augusto Oliveira de; Curi, Rui; Waitzberg, Dan Linetzky

doi:10.1016/j.clnu.2012.12.008

Cited by 68 publications

(92 citation statements)

References 27 publications

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“…Human IL-6 enzyme-linked immunosorbent assay (ELISA) kits (R&D, Minneapolis, MN, USA) were used, according to a technique previously described by our team [24]. IL-6 assays were performed in duplicate, and average values were used.…”

Section: Analysis Of Biochemical Datamentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

et al. 2016

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Section: Analysis Of Biochemical Datamentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

et al. 2016

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“…A randomized controlled study evaluated the effect of omega-3 fatty acid-supplemented total parenteral nutrition (TPN) on the clinical outcomes of patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) showed that postoperative administration of omega-3 fatty acid reduced infection and improved postoperative hepatic function recovery [7]. Short-term pre-operative infusion of fish oil alone has been shown to improve the postoperative immune response of gastrointestinal cancer patients but exhibited no apparent effect on postoperative infections or length of intensive care unit (ICU) and hospital stay [8]. A recent meta analysis evaluated n-3 PUFA-enriched parenteral nutrition (PN) regimens in elective surgical and ICU patients and showed that these regimens are safe and effective in reducing the infection rate and hospital/ICU stay in surgical and ICU patients [9].…”

Section: Introductionmentioning

confidence: 99%

A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors

Wei

Wang

Chen

et al. 2014

Nutr J

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BackgroundNutrients such as ω-3 fatty acids including fish oil components eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress the growth and promote apoptosis of tumor cells, improve immune function and reduce the effects of systemic inflammatory response syndrome. We sought to investigate the effect of ω-3 fish oil fat emulsion-based parenteral nutrition (PN) on nutritional state, immune function, inflammatory reaction, expression of tumor factors and complication incidence in patients after surgical resection of gastric cancer.MethodsForty-eight patients after surgical operation of gastric tumor in hospital were randomly divided into the control group and intervention group. Patients in both groups were treated with iso-nitrogen and iso-caloric parenteral nutrition support. In addition, the intervention group received ω-3 fish oil fat emulsion and the control group received soybean oil. The indicators of nutrition, immune function and inflammation in the two groups were detected on the day before the operation and postoperative day 6. The rate of complication was compared between the two groups.ResultsThere was no significant difference in nutritional state, liver function and renal function between the two groups (P > 0.05). However, the levels of inflammatory markers were significantly decreased (P < 0.01), and the rate of complication was also decreased in the intervention group as compared with the control group.Conclusionsω-3 fish oil fat emulsion-based parenteral nutrition alleviates the inflammatory reaction and reduces the rate of inflammatory complications.

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“…However, despite an attenuation of the inflammatory response with fish oil, the frequency of postoperative infections and the lengths of the ICU and hospital stays remained unchanged for these patients. 34 …”

Section: Clinical Resultsmentioning

confidence: 99%

Strategies for High‐Quality Nutrition Therapy in Brazil

Waitzberg

Correia

2015

J Parenter Enteral Nutr

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It is a great honor to present the 2015 Rhoads Lecture and to discuss strategies for high-quality nutrition therapy (NT), as well as to address the problem of malnutrition in Brazilian hospitals.Dr Rhoads is known for his outstanding achievements in nutrition care, and his unquestionable legacy is demonstrated by the translation of his many scientific papers and books into several languages. The importance of artificial nutrition in the overall care of a patient is reflected in Dr Rhoads's own words: "intravenous feeding is one of the rare things in Medicine that has turned out to be better than its sponsors anticipated." Moreover, when Dr Rhoads was awarded for his contributions and leadership in the field of nutrition, in his speech, he referred to a quote by Nobel laureate economist Milton Friedman: "success lies on the degree to which one's ideas and contributions become embedded in the body of knowledge that comprised one's discipline."1 Indeed, we are here to confirm the veracity of this statement regarding Dr Rhoads's scientific contributions.Accumulating evidence supports the utmost relevancy of artificial nutrition, including oral nutrition, enteral nutrition (EN), and parenteral nutrition (PN), as one of the cornerstones of patient care. Nonetheless, for the full success of NT to be achieved, it is imperative that standardized procedures be followed to prevent life-threatening associated complications and, above all, to avoid the "one-size-fits-all" practice of nutrition, which should be condemned by those following the evidence behind science. History of NT in BrazilHere, the steps that have helped Brazil implement an NT practice are presented and discussed. The statements herein are based on the experience and data of the authors, although we also acknowledge and cite the work of other professionals who have contributed to the development of NT practice in Brazil. In combination, these scientific data highlight the importance of applying advances in laboratory research to the clinical setting to improve patient care. First, we review the history of clinical nutrition in Brazil, with a particular emphasis on the role of nutrition screening and nutrition assessment as demonstrated by a malnutrition prevalence study that encompassed 4000 patients.2 Next follows a discussion of to whom, when, and what NT should be administered, particularly regarding immunonutrition and parenteral lipid emulsions. Finally, strategies that have been used to implement hospital clinical nutrition are presented, with a focus on patients with short bowel syndrome (SBS) and obesity. The outcomes, costs, quality control, and education in clinical practice that are currently involved with these strategies are also presented, as well as how these strategies have the potential to affect perspectives.Very briefly, Brazil is a country that has approximately 200 million inhabitants, 10% of whom are elderly. Life expectancy AbstractStrategies for improving nutrition therapy (NT) are of utmost importance in any healthcare system. The ...

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Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: A randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer

Cited by 68 publications

References 27 publications

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors

Strategies for High‐Quality Nutrition Therapy in Brazil

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