Parenteral viral hepatitis in people with hemophilia: ways to solve the problem

Nikonorova, Marina A.; Карбышева, Н. В.; Кожевникова, Г М; Мамаев, А. Н.; Shevchenko, V. V.; Beskhlebova, O.V.

doi:10.31684/2541-8475.2019.1(13).58-62

Cited by 2 publications

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“…Many pathological conditions are accompanied by the release of cytoplasmic biomarkers into the bloodstream even before cell death (irreversible injury). For example, the release of liver enzymes (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase) and muscle markers (creatine phosphokinase and its isoforms, skeletal troponin isoforms, myoglobin) in the early stages of inflammatory diseases of the hepatobiliary tract and skeletal myopathies, respectively, when there are no symptoms of necrosis yet [70][71][72]. CTs are localized both within the troponin system on thin filaments (structural or non-free CTs fraction) and freely (cytoplasmic or free CTs fraction).…”

Section: Injury To MC Cell Membranes and Increased Permeabilitymentioning

confidence: 99%

Hypertension as One of the Main Non-Myocardial Infarction-Related Causes of Increased Cardiospecific Troponins: From Mechanisms to Significance in Current Medical Practice

Chaulin

2022

J Clin Med Res

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It is well known that many pathological conditions of both cardiovascular diseases (CVDs) (coronary heart disease, myocardial infarction, arrhythmias, myocarditis, cardiomyopathy, etc.) and noncardiac (sepsis, anemia, kidney diseases, diabetes mellitus, etc.) origin in the course of their development cause injury to contractile cardiac muscle cells -myocardial cells (MCs). One of the most sensitive and specific criteria for detecting MC injury are cardiospecific troponins (CTs), which are regulatory protein molecules that are released into the blood serum from MC upon their death or injury. Current methods for determining CTs are called high-sensitive ones, and their main advantage is a very low minimum detectable concentration (limit of detection) (average 1 -10 ng/L or less), which allows early detection of minor MC injury at the earliest stages of CVDs, and therefore they can change the understanding of disease development mechanisms and open up new diagnostic possibilities. One of the most common and dangerous early diseases of the cardiovascular system is hypertension (HT). The novelty of this article lies in the discussion of a new diagnostic direction -predicting the risk of developing CVDs and their dangerous complications in patients with HT by determining the concentration of CTs. In addition, pathophysiological mechanisms underlying MC injury and the release of CTs into the bloodstream and the elimination of CTs into the urine are proposed. This information will contribute to additional fundamental and clinical research to verify the new diagnostic possibility of using CTs in clinical practice (for the management of patients with HT).

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Section: Injury To MC Cell Membranes and Increased Permeabilitymentioning

confidence: 99%

Hypertension as One of the Main Non-Myocardial Infarction-Related Causes of Increased Cardiospecific Troponins: From Mechanisms to Significance in Current Medical Practice

Chaulin

2022

J Clin Med Res

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“…Многие патологические процессы сопровождаются выходом цитоплазматических биомаркеров в русло еще до гибели (необратимого повреждения) клеток. Например, высвобождение печеночных энзимов (аспартатаминотрансферазы, аланинаминтрансферазы, гамма-глутамилтрансферазы) и мышечных маркеров (креактинфосфокиназы и ее изоформ, скелетных изоформ тропонинов, миоглобина) при ранних стадиях воспалительных заболеваний гепатобилиарного тракта и скелетных миопатиях соответственно, когда признаков некроза еще не наблюдается [41,42]. СТ локализуются как в составе тропонинового комплекса на тонких филаментах (структурная или несвободная фракция СТ), так и свободно (цитоплазматическая или свободная фракция СТ).…”

Section: артериальная гипертензия как значимая причина повышения ст м...unclassified

Cardiac troponins as biomarkers of cardiomyocyte damage in arterial hypertension: emphasis on pathophysiological mechanisms

Чаулин¹

2022

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Введение. Многие патологические состояния различного генеза вызывают повреждение кардиомиоцитов (КМЦ). Одним из наиболее чувствительных и специфичных критериев оценки степени повреждения КМЦ являются сердечные тропонины (СТ) - регуляторные белковые молекулы, которые высвобождаются в сыворотку крови из КМЦ при их гибели или повреждении. Новые высокочувствительные методы детекции СТ позволяют выявлять незначительные повреждения КМЦ на самых ранних стадиях сердечно-сосудистых патологий, в связи с чем могут изменить представление о патогенезе и открыть новые диагностические возможности. Цель обзора - обобщение патофизиологических механизмов, лежащих в основе повреждения КМЦ и высвобождения СТ в сосудистое русло при артериальной гипертензии и обсуждение клинического значения изменения уровня СТ у пациентов, страдающих артериальной гипертензией. Методика. При подготовке обзора были использованы отечественные (elibrary/РИНЦ) и зарубежные (Embase, Pubmed/Medline) базы данных. Заключение. В повреждении КМЦ и высвобождении СТ при артериальной гипертензии задействованы следующие патофизиологические механизмы: гипертрофия миокарда, апоптоз КМЦ, повреждение клеточной мембраны КМЦ и повышение ее проницаемости для молекул СТ, а также изменение скорости клубочковой фильтрации в почках. С учетом данных о прогностической ценности уровня СТ при артериальной гипертензии открываются перспективы для использования этих биомаркеров при выборе тактики ведения пациентов. Introduction. Many pathological conditions, both of cardiovascular and extra-cardiac genesis, cause damage to cardiomyocytes (CMC). One of the most sensitive and specific criteria for the detection of CMC damage are cardiac troponins (CT), regulatory protein molecules that are released into the blood from CMC when these cells are killed or damaged. New, highly sensitive methods for detecting CT can identify minor damage to CMC at the earliest stages of cardiovascular pathologies. Thus, these methods may change the understanding of the pathogenesis and suggest new diagnostic possibilities. The aim of this review was to summarize the pathophysiological mechanisms underlying the damage to CMC with the release of CT and to discuss the clinical significance of elevated CT in arterial hypertension. Methods. In the search for literature, Russian (elibrary/RSCI) and international (Embase, Pubmed/Medline) databases were used. The following keywords were used: myocardial damage, cardiac troponins, arterial hypertension, pathophysiology. Conclusion. The CMC damage and the CT release in arterial hypertension are mediated by the following pathophysiological mechanisms: myocardial hypertrophy, CMC apoptosis, damage to the CMC cell membrane and its increased permeability to CT molecules, and changes in the glomerular filtration rate. Taking into account the prognostic value of CT in arterial hypertension, there are prospects for using these biomarkers in choosing tactics for management of patients.

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Parenteral viral hepatitis in people with hemophilia: ways to solve the problem

Cited by 2 publications

References 0 publications

Hypertension as One of the Main Non-Myocardial Infarction-Related Causes of Increased Cardiospecific Troponins: From Mechanisms to Significance in Current Medical Practice

Hypertension as One of the Main Non-Myocardial Infarction-Related Causes of Increased Cardiospecific Troponins: From Mechanisms to Significance in Current Medical Practice

Cardiac troponins as biomarkers of cardiomyocyte damage in arterial hypertension: emphasis on pathophysiological mechanisms

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