Parenteral ziprasidone: a new atypical neuroleptic for emergency treatment of psychosis in Parkinson's disease?

Abstract

This is a report on a case series of five patients with psychosis in Parkinson's disease who were treated successfully with an intramuscular injection of ziprasidone (10-20 mg) for acute agitation. No deterioration of motor function or other clinically relevant side effects were seen.

Psychiatric Care in Parkinson’s Disease

“…136 Based on a case series, Oechsner and Korchounov suggested that an intramuscular injection of ziprasidone (10-20 mg) may successfully treat acute agitation in patients with psychosis in PD, without deterioration of motor function or other clinically relevant side effects. 137 Aripiprazole. No controlled studies have evaluated the use of aripiprazole in patients with PD, and preliminary data are not encouraging.…”

Antidopaminergic therapy for managing comorbidities in patients with Parkinson’s disease

“…Some authors consider ziprasidone an alternative for the emergency treatment of psychosis in PD, 44 but there is insufficient data to support its use under these conditions. 45,46 In addition, one neuroleptic malignant syndrome (NMS) has been reported with ziprasidone therapy. 47 So far, the only published case of NMS precipitated by an antipsychotic drug in a patient with PD was secondary to haloperidol.…”

Combating psychosis in Parkinson’s disease patients: the use of antipsychotic drugs

“…The second open-label report [90] investigated an intramuscular preparation of ziprasidone for the emergency treatment of psychosis in PD. A total of five patients were given gluteal injections of ziprasidone 10 or 20 mg i.m.…”