Network defenders always face the problem of how to use limited resources to make the most reasonable decision. The network attack-defense game model is an effective means to solve this problem. However, existing network attack-defense game models usually assume that defenders will no longer change defense strategies after deploying them. However, in an advanced network attack-defense confrontation, defenders usually redeploy defense strategies for different attack situations. Therefore, the existing network attack-defense game models are challenging to accurately describe the advanced network attack-defense process. To address the above challenges, this paper proposes a defense strategy selection method based on the network attack-defense wargame model. We model the advanced network attack-defense confrontation process as a turn-based wargame in which both attackers and defenders can continuously adjust their strategies in response to the attack-defense posture and use the Monte Carlo tree search method to solve the optimal defense strategy. Finally, a network example is used to illustrate the effectiveness of the model and method in selecting the optimal defense strategy.