Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies

Guan, Hongyan; Wu, Qi‐Jun; Gong, Ting-Ting

doi:10.1158/1055-9965.epi-13-0759-t

Cited by 29 publications

(25 citation statements)

References 47 publications

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“…Recent meta-analyses of epidemiologic studies suggested that increasing parity and prior hysterectomy, both factors associated with decreased estrogen exposure, thus reducing the risk of breast cancer, increase the risk of RCC [27–29]. However, a recent study of second primaries among an international cohort of breast cancer patients found an excess risk of kidney cancer [30].…”

Section: Discussionmentioning

confidence: 99%

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

et al. 2016

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Purpose To examine the incidence of secondary primary malignancies in patients with renal cortical neoplasms. Methods Between January 1989 and July 2010, 3647 patients underwent surgery at our institution for a renal cortical neoplasm and were followed through 2012. Occurrence of other malignancies was classified as antecedent, synchronous, or subsequent. All patients with antecedent malignancies (n = 498) and a randomly selected half of those with synchronous malignancies (n = 83) were excluded. The expected number of second primaries was calculated by multiplying Surveillance, Epidemiology, and End Results Program incidence rates of renal cortical neoplasms by person-years at risk within categories of age, sex, and year of diagnosis. The standardized incidence ratio (SIR) was calculated as observed cancers divided by expected incidence of the cancer, with approximation to the exact Poisson test used to obtain confidence intervals (CI) and p values. Results Of 3066 patients with renal cortical neoplasms, 267 had a second primary cancer; the five most common in men were prostate, colorectal, bladder, lung, and non-Hodgkin’s lymphoma; the five most common in women were breast, colorectal, lung, endometrium, and thyroid. Men demonstrated higher than expected thyroid cancer rate (SIR 5.0; 95 % CI 1.83–10.88, p = 0.002), and women had higher than expected rates of stomach cancer (SIR 5.0; 95 % CI 1.61–11.67, p = 0.004) and thyroid cancer (SIR 4.62; 95 % CI 1.69–10.05, p = 0.003). Conclusions The incidence of certain types of second malignancies may be higher in patients after diagnosis of renal cortical neoplasms compared to the general population. These observations can inform clinical follow-up in kidney cancer survivorship and future research studies.

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Section: Discussionmentioning

confidence: 99%

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

et al. 2016

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“…Thus, we had statistical power to detect moderate and weak associations. Meanwhile, similar to our previous studies [44,45], we carried out numerous subgroup and sensitivity analyses to explore the heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

“…If no estimate was presented in a given study, we calculated it and its 95 % CI according to the raw data presented in the article [27,38]. Similar to our previous studies [44,45], we did not assess study quality using a quality score, but investigated whether specific study characteristics, such as study design and adjustment for confounders, which are indicators of study quality, influenced the results in subgroup analyses.…”

Section: Data Extractionmentioning

confidence: 99%

Nonlinear reduction in risk for colorectal cancer by oral contraceptive use: a meta-analysis of epidemiological studies

Luan

Gong

et al. 2014

Cancer Causes Control

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“…We also reviewed the references of all included studies for additional publications. We followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) for conducting and reporting meta-analyses [34]–[36].…”

Section: Methodsmentioning

confidence: 99%

Parity and Pancreatic Cancer Risk: A Dose-Response Meta-Analysis of Epidemiologic Studies

Guan

et al. 2014

PLoS ONE

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BackgroundPrevious epidemiologic studies have reported inconsistent results between parity and pancreatic cancer (PC) risk. To our knowledge, a comprehensive and quantitative assessment of this association has not been conducted.MethodsRelevant published studies of parity and PC were identified using MEDLINE (PubMed) and Web of Science databases until November 2013. Two authors (H-BG and LW) independently assessed eligibility and extracted data. Eleven prospective and 11 case-control studies reported relative risk (RR) estimates and 95% confidence intervals (CIs) of PC associated with parity. Fixed- and random-effects models were used to estimate the summary RR depending on the heterogeneity of effects.ResultsThe summary RR for PC comparing the highest versus lowest parity was 0.86 (95% CI: 0.73–1.02; Q = 50.49, P<0.001, I 2 = 58.4%). Significant inverse associations were also observed in the studies that adjusted for cigarette smoking (RR = 0.81; 95% CI: 0.68–0.98), Type 2 diabetes mellitus (RR = 0.83; 95% CI: 0.75–0.93), and those that included all confounders or important risk factors (RR = 0.85; 95% CI: 0.76–0.96). Additionally, in the dose-response analysis, the summary RR for per one live birth was 0.97 (95% CI: 0.94–1.01; Q = 62.83, P<0.001, I 2 = 69.8%), which also indicated a borderline statistically significant inverse effect of parity on PC risk. No evidence of publication bias and significant heterogeneity between subgroups were detected by meta-regression analyses.ConclusionIn summary, these findings suggest that higher parity is associated with a decreased risk of PC. Future large consortia or pooled studies are warranted to fully adjust for potential confounders to confirm this association.

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Parity and Kidney Cancer Risk: Evidence from Epidemiologic Studies

Cited by 29 publications

References 47 publications

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

Nonlinear reduction in risk for colorectal cancer by oral contraceptive use: a meta-analysis of epidemiological studies

Parity and Pancreatic Cancer Risk: A Dose-Response Meta-Analysis of Epidemiologic Studies

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