Parity and Risk of Metabolic Syndrome Among Chinese Women

Wu, Jing; Xu, Gui-Ping; Shen, Lijun; Zhang, Yanmei; Song, Lulu; Yang, Shuo; Yang, Handong; Yuan, Jing; Liang, Yuan; Wang, Youjie; Wu, Tangchun

doi:10.1089/jwh.2014.5134

Cited by 26 publications

(36 citation statements)

References 38 publications

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“…This finding is consistent with prior studies among other racial and ethnic groups that observed significant relationships between increasing parity and overall MetS, 12,13,15,16 including statistically significant variations by history of gestational diabetes. 14 Adjustment for BMI attenuated these earlier findings and the associations were no longer statistically significant for some.…”

Section: Discussionsupporting

confidence: 92%

“…While our results are similar to those from studies among Chinese and U.S. populations that found a linear association between increasing parity and both higher waist circumference 13 and an increased prevalence of abdominal obesity (waist circumference >88cm), 12 respectively, they are in contrast to studies of Bangladeshi 17 and Iranian 15 women where no association was observed between parity and waist circumference, after adjustment for similar socio-demographic, lifestyle, and reproductive factors. Similarly, a few prior studies also noted a linear association between increasing parity and lower HDL-C 12,13,15 while others found no association. 16,17 In contrast to our findings, most prior studies did not find an association between parity and elevated fasting glucose, 12,13,17 and a few studies observed a linear association between increasing parity and elevated triglycerides.…”

Section: Discussionsupporting

confidence: 83%

“…Similarly, a few prior studies also noted a linear association between increasing parity and lower HDL-C 12,13,15 while others found no association. 16,17 In contrast to our findings, most prior studies did not find an association between parity and elevated fasting glucose, 12,13,17 and a few studies observed a linear association between increasing parity and elevated triglycerides. 12,15,16 The most consistent finding across studies, including the present study, was the lack of association observed between parity and blood pressure.…”

Section: Discussionmentioning

confidence: 63%

“…12,15,16 The most consistent finding across studies, including the present study, was the lack of association observed between parity and blood pressure. 12,13,15,16 Overall, these results suggest that parity may alter women’s metabolic profiles. However, the differences in results across prior studies indicates that specific MetS components may be more or less susceptible to change depending on the population.…”

Section: Discussionmentioning

confidence: 72%

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Parity and Components of the Metabolic Syndrome Among US Hispanic/Latina Women

Vladutiu¹,

Siega‐Riz²,

Stuebe³

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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Background Physiologic adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life. Methods and Results The association between parity and metabolic syndrome (MetS) was examined among 7,467 Hispanic/Latina women of diverse backgrounds, aged 18–74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008–2011. MetS components were defined according to AHA/NHLBI criteria and included abdominal obesity, elevated triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting glucose. Logistic regression models estimated odds ratios adjusting for socio-demographic, behavioral, and reproductive characteristics. At HCHS/SOL baseline, women reported none (21.1%), one (19.9%), two (25.7%), three (18.6%), four (8.8%), and five or more (5.9%) live births. Compared to women with one birth, those with four births had the highest odds of abdominal obesity (OR=2.0, 95%CI 1.5, 2.8) and overall MetS (OR=1.4, 95%CI 1.0, 2.0) and those with five or more births had the highest odds of low HDL cholesterol (OR=1.5, 95%CI 1.2, 2.0) and elevated fasting glucose (OR=1.6, 95%CI 1.1, 2.4), after adjusting for age, background, education, marital status, income, nativity, smoking, physical activity, menopause, oral contraceptive use, hormone therapy, and field center. Further adjustment for percent body fat attenuated these associations. No associations were observed between parity and elevated triglycerides or high blood pressure. Conclusions Higher parity is associated with an increased prevalence of selected components of the MetS among Hispanic/Latina women in the U.S. High parity among Hispanics/Latinas with a high prevalence of abdominal obesity suggests high risk for metabolic dysregulation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 72%

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Parity and Components of the Metabolic Syndrome Among US Hispanic/Latina Women

Vladutiu¹,

Siega‐Riz²,

Stuebe³

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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“…Furthermore, a woman’s risk of metabolic syndrome and its components increases with each pregnancy [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and its components in Polish women of childbearing age: a nationwide study

et al. 2017

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BackgroundAbnormal body mass and related metabolic disorders may affect female reproductive health. The purpose of the study was to determine the prevalence of underweight, overweight, obesity, lipid and glucose metabolism disorders, hypertension, and metabolic syndrome, among Polish women of childbearing age.MethodsOne thousand five hundred eighty-eight non-pregnant Polish women of childbearing age (20–49 years) who participated in the Multi-Centre National Population Health Examination Survey (WOBASZ II study) in 2013–2014, were assigned to 3 age groups: 20–29 years (n = 403), 30–39 years (n = 600) and 40–49 years (n = 585). Measurements of weight, height, waist circumference, blood pressure, blood lipids, and blood glucose were taken. For statistical analysis, the Kruskal-Wallis, Chi-Square, and Cohran-Armitage tests were used.ResultsOf the participants, 4.3% were determined to be underweight, 25.2% were overweight, 15% were obese, and 53.1% had abdominal obesity. With age, the prevalence of both excessive body mass and abdominal obesity tended to increase, and that of underweight to decrease. Frequency of hypercholesterolemia and hypertriglyceridemia found in the whole group were 50% and 12.6% respectively, and also tended to rise with age. Low serum HDL-cholesterol (high density lipoprotein cholesterol) levels were found in 15.1% of the participants. Prevalence of impaired fasting glucose in the whole group was 8.2% and tended to increase with age. Diabetes was found in 1.2% of the participants and its prevalence also tended to rise with age, at the borderline of significance. Frequency of arterial hypertension and metabolic syndrome in the whole group was 15.7% and 14.1% respectively and both tended to increase with age.ConclusionsOverweight and obesity, especially of abdominal type, and the related metabolic abnormalities are common in Polish women of childbearing age. Their prevalence tends to increase with age. Underweight is relatively common in the youngest age group.

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