2017
DOI: 10.21776/ub.mnj.2017.003.01.7
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Parkinson and Stem Cell Therapy

Abstract: ABSTRAKPenyakit parkinson merupakan gangguan neurodegeneratif yang bersifat progesif yang mengenai gerakan atau kontrol terhadap gerakan. Penyakit ini sering terjadi pada individu berusia lebih dari 60 tahun.Etiologi penyakit parkinson diduga disebabkan oleh kombinasi faktor genetik dan lingkungan. Karena harapan hidup secara keseluruhan meningkat, maka jumlah orang dengan penyakit parkinson akan meningkat di masa depan.Terapi dari penyakit parkinson dapat menggunakan dengan terapi farmakologi maupun terapi no… Show more

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Cited by 5 publications
(6 citation statements)
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“…Kerusakan sel saraf di substantia nigra, wilayah otak yang bertanggung jawab untuk produksi dopamin, adalah akar penyebab penyakit Parkinson [4]. Dopamin berfungsi sebagai pembawa pesan antara otak dan daerah sistem saraf yang membantu mengatur dan mengkoordinasikan gerakan tubuh.…”
Section: Pendahuluanunclassified
“…Kerusakan sel saraf di substantia nigra, wilayah otak yang bertanggung jawab untuk produksi dopamin, adalah akar penyebab penyakit Parkinson [4]. Dopamin berfungsi sebagai pembawa pesan antara otak dan daerah sistem saraf yang membantu mengatur dan mengkoordinasikan gerakan tubuh.…”
Section: Pendahuluanunclassified
“…Parkinson's disease is a neurodegenerative disorder characterized by classic motor symptoms, namely bradykinesia, rigidity, and tremors (Gunawan et al, 2017). This disease attacks nerve cells gradually in the midbrain where the part regulates body movements.…”
Section: Introductionmentioning
confidence: 99%
“…While the preference is roughly the same for both sexes, men are more susceptible to its effects with a ratio of 3:2. 3 Parkinson's is a progressive neurodegenerative disease characterized by the loss of neurons in the substantia nigra resulting in decreased dopamine production and accumulation of Lewy bodies (LB) due to the formation of α-synuclein aggregates. The LB formation impairs the ubiquitin-proteasome degradation process, causing the failure of adenosine triphosphate (ATP) production, which results in mitochondrial dysfunction.…”
Section: Introductionmentioning
confidence: 99%
“…All treatment is known to relieve and overcome the symptoms of Parkinson's due to improving the Activity of Daily Living (ADL) and Quality of Life (QQL), but they do not stop dopamine degradation. 3,8 This condition encourages research to develop better neuroprotective therapy strategies as supportive therapies for Parkinson's disease. The supportive therapy should be highly effective for the disease remedy and common side effects for patients.…”
Section: Introductionmentioning
confidence: 99%