Parkinson’s Disease–An Introduction

Rawat, Chandra Shekhar; Pandey, Sanjay

doi:10.1007/978-981-16-3056-9_1

Cited by 2 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Annually, over 60,000 Americans are identified with Parkinson’s disease ( Chakraborty et al, 2020 ). Motor symptoms such as bradykinesia with stiffness (hypomimia), resting tremor, freezing, festination, dyskinesia, dystonia, sialorrhea, micrographia shuffling gait, and hypophonia along with postural instability at a later phase, define Parkinson’s disease ( Rawat and Pandey, 2022 ). Non-motor symptoms such as dementia, depression, seborrheic dermatitis, excessive sweating, orthostatic hypotension, weight loss, hallucinations, delusions, and autonomic dysfunction may also be present ( Goldman and Guerra, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Environmental Toxicants on Neurodegenerative Disorders

Nabi

Tabassum

2022

Front. Toxicol.

View full text Add to dashboard Cite

Neurodegeneration leads to the loss of structural and functioning components of neurons over time. Various studies have related neurodegeneration to a number of degenerative disorders. Neurological repercussions of neurodegeneration can have severe impacts on the physical and mental health of patients. In the recent past, various neurodegenerative ailments such as Alzheimer’s and Parkinson’s illnesses have received global consideration owing to their global occurrence. Environmental attributes have been regarded as the main contributors to neural dysfunction-related disorders. The majority of neurological diseases are mainly related to prenatal and postnatal exposure to industrially produced environmental toxins. Some neurotoxic metals, like lead (Pb), aluminium (Al), Mercury (Hg), manganese (Mn), cadmium (Cd), and arsenic (As), and also pesticides and metal-based nanoparticles, have been implicated in Parkinson’s and Alzheimer’s disease. The contaminants are known for their ability to produce senile or amyloid plaques and neurofibrillary tangles (NFTs), which are the key features of these neurological dysfunctions. Besides, solvent exposure is also a significant contributor to neurological diseases. This study recapitulates the role of environmental neurotoxins on neurodegeneration with special emphasis on major neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease.

show abstract

Section: Introductionmentioning

confidence: 99%