Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies

Zhang, Xuxiang; Tang, Beisha; Guo, Jifeng

doi:10.1186/s40035-023-00392-8

Cited by 29 publications

(16 citation statements)

References 309 publications

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“…Besides, emerging research suggested a connection between the gut microbiome and neurodegenerative conditions like Parkinson’s disease. Changes in the gut microbiome composition might influence the development and progression of neurodegenerative diseases through the gut-brain axis ( Zhu et al, 2021 ; Zhang et al, 2023a ). From a similar perspective, this study analyzed the impact of the non-cutaneous microbial environment on hypertrophic scarring.…”

Section: Discussionmentioning

confidence: 99%

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Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

Xue,

Zhang,

et al. 2024

Front. Microbiol.

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Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases through the intricate interplay between gut microbiota and the host. However, the precise nature of the causal link between gut microbiota and hypertrophic scarring remains uncertain. In this study, after compiling summary data from genome-wide association studies (GWAS) involving 418 instances of gut microbiota and hypertrophic scarring, we conducted a bidirectional Mendelian randomization (MR) to investigate the potential existence of a causal relationship between gut microbiota and the development of hypertrophic scar and to discern the directionality of causation. By utilizing MR analysis, we identified seven causal associations between gut microbiome and hypertrophic scarring, involving one positive and six negative causal directions. Among them, Intestinimonas, Ruminococcus2, Barnesiella, Dorea, Desulfovibrio piger, and Ruminococcus torques act as protective factors against hypertrophic scarring, while Eubacterium rectale suggests a potential role as a risk factor for hypertrophic scars. Additionally, sensitivity analyses of these results revealed no indications of heterogeneity or pleiotropy. The findings of our MR study suggest a potential causative link between gut microbiota and hypertrophic scarring, opening up new ways for future mechanistic research and the exploration of nanobiotechnology therapies for skin disorders.

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Section: Discussionmentioning

confidence: 99%

“…10. 3389/fmicb.2024.1345717 Frontiers in Microbiology 07 frontiersin.org through the gut-brain axis (Zhu et al, 2021;Zhang et al, 2023a). From a similar perspective, this study analyzed the impact of the non-cutaneous microbial environment on hypertrophic scarring.…”

Section: Discussionmentioning

confidence: 99%

Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

Xue,

Zhang,

et al. 2024

Front. Microbiol.

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“…Studies have linked gut microbiota imbalance to the development of PD, where dysbiosis increases gut permeability, enabling harmful substances to trigger inflammation. Activation of immune cells by microbial products releases inflammatory molecules that damage dopaminergic neurons through neuroinflammation, facilitated by the vagus nerve (Zhang X. et al, 2023).…”

Section: Parkinson's Diseasementioning

confidence: 99%

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Adamu,

Li,

Gao

et al. 2024

Front. Aging Neurosci.

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Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species are synthesized. Neuroinflammation is a key process that helps protect the brain from pathogens, but inappropriate, or protracted inflammation yields pathological states such as Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, and other neurodegenerative disorders that showcase various pathways of neurodegeneration distributed in various parts of the CNS. This review reveals the major neuroinflammatory signaling pathways associated with neurodegeneration. Additionally, it explores promising therapeutic avenues, such as stem cell therapy, genetic intervention, and nanoparticles, aiming to regulate neuroinflammation and potentially impede or decelerate the advancement of these conditions. A comprehensive understanding of the intricate connection between neuroinflammation and these diseases is pivotal for the development of future treatment strategies that can alleviate the burden imposed by these devastating disorders.

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“…20−24 Besides this, microbial treatment has also drawn interest lately for its potential in alleviating PD disease symptoms. 25 Administration of gut microenvironment modifying agents may afford neuroprotection by regulating the gut−brain axis, controlling gut dysbiosis. Probiotic supplementation containing a variety of microbes can effectively alleviate symptoms of PD by addressing various cellular and molecular processes such as oxidative stress, apoptosis, and inflammatory and anti-inflammatory pathways.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Journey from the Gut to the Brain: Decoding Neurodegeneration–Gut Connection in Parkinson’s Disease

Bhardwaj,

Singh,

Kumar

2024

ACS Chem. Neurosci.

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Parkinson's disease, a classical motor disorder affecting the dopaminergic system of the brain, has been as a disease of the brain, but this classical notion has now been viewed differently as the pathology begins in the gut and then gradually moves up to the brain regions. The microorganisms in the gut play a critical role in maintaining the physiology of the gut from maintaining barrier integrity to secretion of microbial products that maintain a healthy gut state. The pathology subsequently alters the normal composition of gut microbes and causes deleterious effects that ultimately trigger strong neuroinflammation and nonmotor symptoms along with characteristic synucleopathy, a pathological hallmark of the disease. Understanding the complex pathomechanisms in distinct and established preclinical models is the primary goal of researchers to decipher how exactly gut pathology has a central effect; the quest has led to many answered and some openended questions for researchers. We summarize the popular opinions and some contrasting views, concise footsteps in the treatment strategies targeting the gastrointestinal system.

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Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies

Cited by 29 publications

References 309 publications

Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Unveiling the Journey from the Gut to the Brain: Decoding Neurodegeneration–Gut Connection in Parkinson’s Disease

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