Parkinsonism as a Manifestation of Neuropsychiatric Systemic Lupus Erythematosus: A Case Report and Literature Review

Reversible Acute Parkinsonism and Unusual Neuroimaging Findings in Systemic Lupus Erythematosus

“…9 Tang et al reported on a 17-year-old patient with parkinsonism and SLE with no response with methylprednisolone and cyclophosphamide, but had a marked improvement with intrathecal injection of methotrexate and dexamethasone. 10 In conclusion, this instructive and unusual case report shows that acute parkinsonism should direct diagnosis to SLE, and that neurological symptoms improve after immunotherapy. Furthermore, we showed that the presynaptic pathway is preserved and presume an immune-mediated pathophysiological mechanism as the most likely explanation.…”

“…Kwong et al reported on 2 patients with SLE who developed parkinsonian features, which presented poor response with methylprednisolone and cyclophosphamide, but had a complete recovery with intravenous immunoglobulin . Tang et al reported on a 17‐year‐old patient with parkinsonism and SLE with no response with methylprednisolone and cyclophosphamide, but had a marked improvement with intrathecal injection of methotrexate and dexamethasone …”