Parkinsonism in a population of northern Tanzania: a community-based door-to-door study in combination with a prospective hospital-based evaluation

Winkler, Andrea Sylvia; Tütüncü, Esra; Trendafilova, Anna; Meindl, Michael; Kaaya, John; Schmutzhard, Erich; Kassubek, Jan

doi:10.1007/s00415-009-5420-z

Cited by 23 publications

(11 citation statements)

References 21 publications

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“…Of the 47 included studies, 21 were performed in Asia, 11 in Europe, 5 in Africa, 4 in Australia, 4 in South America, and 2 in North America (see Supplemental Data Table e‐1). Most studies used a two‐stage procedure to identify individuals with PD.…”

Section: Resultsmentioning

confidence: 99%

The prevalence of Parkinson's disease: A systematic review and meta‐analysis

et al. 2014

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Parkinson's Disease (PD) is a common neurodegenerative disorder. We sought to synthesize studies on the prevalence of PD to obtain an overall view of how the prevalence of this disease varies by age, by sex, and by geographic location. We searched MEDLINE and EMBASE for epidemiological studies of PD from 1985 to 2010. Data were analyzed by age group, geographic location, and sex. Geographic location was stratified by the following groups: 1) Asia, 2) Africa, 3) South America, and 4) Europe/North America/Australia. Meta-regression was used to determine whether a significant difference was present between groups. Forty-seven studies were included in the analysis. Meta-analysis of the worldwide data showed a rising prevalence of PD with age (all per 100,000): 41 in 40 to 49 years; 107 in 50 to 59 years; 173 in 55 to 64 years; 428 in 60 to 69 years; 425 in 65 to 74 years; 1087 in 70 to 79 years; and 1903 in older than age 80. A significant difference was seen in prevalence by geographic location only for individuals 70 to 79 years old, with a prevalence of 1,601 in individuals from North America, Europe, and Australia, compared with 646 in individuals from Asia (P < 0.05). A significant difference in prevalence by sex was found only for individuals 50 to 59 years old, with a prevalence of 41 in females and 134 in males (P < 0.05). PD prevalence increases steadily with age. Some differences in prevalence by geographic location and sex can be detected.

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Section: Resultsmentioning

confidence: 99%

The prevalence of Parkinson's disease: A systematic review and meta‐analysis

et al. 2014

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“…Among the 40-year-old American population, the risk of PD in men is about 2%, while in women is 1.3% [11]. The age-adjusted prevalence of PD reflects morbidity and mortality, which in Africa is lower than that in Europe, the United States, and Asia [12][13][14]. Currently, there are fewer morbidity data related to racial or ethnic, but the incidence varies according to the current research.…”

Section: Epidemiology Study Of Parkinson's Diseasementioning

confidence: 86%

What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Fan

Jabeen

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aim. This study was aimed at investigating the effects and molecular mechanisms of physical activity intervention on Parkinson’s disease (PD) and providing theoretical guidance for the prevention and treatment of PD. Methods. Four electronic databases up to December 2019 were searched (PubMed, Springer, Elsevier, and Wiley database), 176 articles were selected. Literature data were analyzed by the logic analysis method. Results. (1) Risk factors of PD include dairy products, pesticides, traumatic brain injury, and obesity. Protective factors include alcohol, tobacco, coffee, black tea, and physical activity. (2) Physical activity can reduce the risk and improve symptoms of PD and the beneficial forms of physical activity, including running, dancing, traditional Chinese martial arts, yoga, and weight training. (3) Different forms of physical activity alleviate the symptoms of PD through different mechanisms, including reducing the accumulation of α-syn protein, inflammation, and oxidative stress, while enhancing BDNF activity, nerve regeneration, and mitochondrial function. Conclusion. Physical activity has a positive impact on the prevention and treatment of PD. Illustrating the molecular mechanism of physical activity-induced protective effect on PD is an urgent need for improving the efficacy of PD therapy regimens in the future.

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“…Indian studies reported a high prevalence of epilepsy in 20.6% [ 13 ] while in rural Tanzania, the prevalence of epilepsy was 2.91/1000 adults [ 26 ] and 4.9% in a rural area of Bilomo in Cameroon [ 27 ]. Other studies in Sub-Saharan Africa have reported crude yearly stroke incidence rates of 94.5-107.9/100, 000 [ 17 ], 20/100,000 for Parkinson disease [ 28 ], 41/100,000 for essential tremor [ 29 ], 4.3% for 1-year prevalence of migraine headache [ 16 ], and 0.1% for hospital-based prevalence of Parkinsonism [ 30 ]. The classification of neurological diseases in the elderly in urban Africa is important in terms of diagnostic approach, therapy and prognosis.…”

Section: Discussionmentioning

confidence: 99%

The pattern of neurological diseases in elderly people in outpatient consultations in Sub-Saharan Africa

et al. 2015

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BackgroundNeurological diseases are frequent in older adults, affecting between 5% and 55% of people age 55 and older. They are associated with a high risk for adverse health outcomes, including mortality, disability, institutionalization and hospitalization. Little is known about the epidemiology and clinical pattern of neurological disorders of the elderly in developing countries. Although many studies have demonstrated the areas where the burden of neurological diseases lies, elderly patients in Sub-Saharan Africa have received little attention. We performed this descriptive study to understand the burden of disease faced by Cameroonian neurologists and geriatricians.MethodsThe records of all out-patient neurological consultations from May 2005 to December 2011 were collected at the Clinique Bastos, the sole clinic with adult neurological consultations during the study period in Yaoundé, the political capital of Cameroon. All medical records were reviewed by a neurologist and neurological diagnoses were classified according to ICD-10.ResultsAmong a total of 912 patients, 187 (20.5%) were aged 60 and older. According to the ICD-10 classification, episodic and paroxysmal disorders were present in 18.7% of patients, extrapyramidal and movement disorders in 14.6%, and nerve, nerve root and plexus disorders in 13.3%. The most common neurological diseases of the elderly in this study were lumbar arthrosis (14%), dementia (Alzheimer’s type, vascular) (12.4%), Parkinson’s disease (10.2%), and polyneuropathy (9.1%).ConclusionDegenerative diseases like dementia and Parkinson’s disease as well as strokes and headaches are frequently encountered neurological diseases in elderly patients in Sub-Saharan Africa. It is important that standard treatment regimes, often Ministry of Public Health based, are adhered to these diseases.

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Parkinsonism in a population of northern Tanzania: a community-based door-to-door study in combination with a prospective hospital-based evaluation

Cited by 23 publications

References 21 publications

The prevalence of Parkinson's disease: A systematic review and meta‐analysis

The prevalence of Parkinson's disease: A systematic review and meta‐analysis

What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

The pattern of neurological diseases in elderly people in outpatient consultations in Sub-Saharan Africa

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