What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Fan, Baozhu; Jabeen, Riffat; Bo, Bing; Guo, Chunlei; Meng-jie, Han; Zhang, Hui; Cen, Juan; Ji, Xin‐Ying; Wei, Jianshe

doi:10.1155/2020/4293071

Cited by 45 publications

(29 citation statements)

References 188 publications

(198 reference statements)

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“…Diet regulation and exercise not only reduce body weight but also affect synaptic plasticity and protect against cognitive and neurological diseases. Studies have shown that long-term participation in reasonable physical exercises, such as running, boxing, swimming and dancing, has a beneficial effect on the motor and nonmotor symptoms of PD patients, which greatly improves their quality of life [ 106 , 107 ]. Physical exercise also reduces the accumulation of α-Syn, inflammation and oxidative stress; increases the level of brain-derived neurotrophic factor (BDNF); and enhances the function of mitochondria to maintain cellular energy metabolism [ 107 ].…”

Section: Obesity Hypercholesterolemia and Pdmentioning

confidence: 99%

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism

Liu¹,

Jiao²,

Du³

et al. 2021

Aging and disease

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Section: Obesity Hypercholesterolemia and Pdmentioning

confidence: 99%

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism

Liu¹,

Jiao²,

Du³

et al. 2021

Aging and disease

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“…This debilitating fear of movement can also be considered a factor that intensifies one’s limited activity levels. At all times, it is important to bear in mind that moderate physical activity has a positive impact on PD and should be used as a treatment to alleviate symptoms such as motor dysfunction, cognitive deficits, and depression [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Jiménez-Cebrián

Becerro-de-Bengoa-Vallejo

Iglesias

et al. 2021

IJERPH

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Background: Kinesiophobia can be an obstacle to physical and motor activity in patients with Parkinson’s disease (PD). PD affects patients’ independence in carrying out daily activities. It also impacts a patient’s biopsychosocial well-being. The objective of this study was to analyze the levels and scores of kinesiophobia in PD patients and compare them with healthy volunteers. Methods: We deployed a case-control study and recruited 124 subjects (mean age 69.18 ± 9.12). PD patients were recruited from a center of excellence for Parkinson’s disease (cases n = 62). Control subjects were recruited from the same hospital (control n = 62). Kinesiophobia total scores and categories were self-reported using the Spanish version of the Tampa Scale of Kinesiophobia (TSK-11). Results: Differences between cases and control groups were analyzed using the Mann–Whitney U test. Statistically significant differences (p < 0.05) were shown between groups when comparing kinesiophobia categories (or levels) and total scores, revealing higher kinesiophobia symptoms and levels in PD patients. All of the PD patients reported some degree of kinesiophobia (TSK-11 ≥ 18), while the majority of PD patients (77.3%) had kinesiophobia scores rated as moderate to severe (TSK-11 ≥ 25). On the other hand, ~45.1% of controls reported no or slight kinesiophobia and 53.2% reported moderate kinesiophobia. Conclusions: Total kinesiophobia scores were significantly higher in PD patients compared with healthy controls, with moderate to severe kinesiophobia levels prevailing in PD patients. Therefore, individuals living with PD should be evaluated and controlled in order to detect initial kinesiophobia symptoms.

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“…Furthermore, according to Fan et al [ 18 ], physical exercise, especially those performed at moderate to vigorous intensities, has a positive impact on PD through multiple mechanisms, including reduction of α-synuclein protein accumulation, decrease in inflammation and oxidative stress, improvement in brain-derived neurotrophic factor (BDNF) activity, nerve regeneration, and mitochondrial function. Furthermore, some authors have shown that endurance exercise is safe and well-tolerated for people with PD from a cardiovascular point of view, which supports their recommendation for this population [ 19 ].…”

Section: Introductionmentioning

confidence: 66%

Effect of the combination of automated peripheral mechanical stimulation and physical exercise on aerobic functional capacity and cardiac autonomic control in patients with Parkinson’s disease: a randomized clinical trial protocol

Zelada-Astudillo

Moreno

Herrera-Santelices

et al. 2021

Trials

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Background Automated peripheral mechanical stimulation (AMPS) has been proposed as a new complementary therapy with potential for improving motor and cardiovascular abnormalities in Parkinson’s disease (PD). However, AMPS long-term effects and its combination with physical exercise are unknown. Thus, this study aims to compare the effects of a program of 12 weeks of physical exercise with a 12-week intervention program combining physical exercise and AMPS on the aerobic capacity, cardiac autonomic control, and gait parameters in patients with PD. Methods A randomized, controlled clinical trial will be conducted. Older volunteers with PD will be randomly assigned to one of the two groups studied: (1) exercise or (2) AMPS + exercise. Both groups will undergo an exercise program of 24 sessions, for 12 weeks, performed twice a week. Before exercise sessions, the group AMPS + exercise will receive a session of active AMPS, while the group exercise will receive an AMPS sham intervention. Shapiro-Wilk’s and Levene’s tests will be used to check for data normality and homogeneity, respectively. In case parametric assumptions are fulfilled, per-protocol and intention-to-treat analyses will be performed using a mixed model analysis of variance to check for group*time interaction. Significance level will be set at 5%. Discussion Several non-pharmacological treatment modalities have been proposed for PD, focusing primarily on the reduction of motor and musculoskeletal disorders. Regular exercise and motor training have been shown to be effective in improving quality of life. However, treatment options in general remain limited given the high prevalence and adverse impact of these disorders. So, developing new strategies that can potentiate the improvement of motor disabilities and also improve non-motor symptoms in PD is relevant. It is expected that the participants from both groups will improve their quality of life, gait parameters, and their cardiac autonomic control, with greater improvements being observed in the group combining active AMPS and physical exercise. Trial registration ClinicalTrials.gov NCT04251728. Registered on February 05, 2020.

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What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Cited by 45 publications

References 188 publications

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Effect of the combination of automated peripheral mechanical stimulation and physical exercise on aerobic functional capacity and cardiac autonomic control in patients with Parkinson’s disease: a randomized clinical trial protocol

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