Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure

Abstract

The present study is a retrospective analysis of 11 cases with severe acute liver failure combined with multiple organ dysfunction syndrome (MODS) performed during the period June, 2012 to December, 2014. After part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration treatment, good curative effects were obtained and the main clinical symptoms and biochemical index were significantly improved. Following treatment, 8 of the 11 patients survived at a survival rate of 72.7%, and 3 patients succumbed with a mortality of 27.3%. The results suggested that part of plasmapheresis with plasma filtration adsorption combined with continuous venovenous hemodiafiltration (CVVHDF) treatment is beneficial in the removal of metabolites and toxins. Additonally, it can effectively improve liver function and clinical symptoms, improve hepatic encephalopathy, correct the disorder of internal environment, and improve the prognosis of patients.

Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency

“…Previous reports have suggested that patients with hepatic coma have worse clinical outcomes. [ 14 15 ] Hence, it may seem prudent to treat these patients aggressively. Extracorporeal therapy, other than hemodialysis, has been tried in such cases, with good results.…”

The role of plasma exchange in hyperbilirubinemia from a different perspective

“…In other words, it helps to maintain the biochemical and homeostatic balance in the body. By this method, the compensation of liver metabolism will lead to the necessary time for the patient's own liver regeneration to occur 3,8,9 . In recent years, it has been shown that PE is effective in the emergency treatment of liver failure [10][11][12][13] .…”

Perioperative management of patients with concomitant liver diseases

“…-Плазмосорбция и плазмофильтрация эффективно снижают уровень билирубина и других токсических метаболитов, образующихся на фоне механической желтухи и холестаза [112][113][114][115]. Уровень достоверности (доказательности) В. Уровень убедительности рекомендации IIa.…”

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