Partial characterization of liver proteins following exposure to mercury

Bryan, Sara E.; Hayes, Eugene F.

doi:10.1016/0014-5793(72)80153-4

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Trace amounts of nonbound mercury isolated along with chromatin were probably contributed by cytoplasm, yet the data indicated that a much larger portion was present as an intrinsic constituent of chromatin and that the metal had a strong tendency to interact with and to induce structural alterations in the nuclear material. It was known from previous experiments that the sublethal levels of mercury used in the present study were seemingly nontoxic levels in that animals lived as long as controls and appeared healthy throughout the study (Bryan and Hayes, 1972); yet serum proteins monitored by electrophoresis (Bryan and Bright, 1973) which were markedly altered after short term ingestion of the metal appeared normal after prolonged exposure. The mechanisms which bring about such physiological adaptations in mammals are not known.…”

Section: Discussionmentioning

confidence: 62%

Metal constituents of chromatin. Interaction of mercury in vivo

Bryan¹,

Guy²,

Hardy³

1974

Biochemistry

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Section: Discussionmentioning

confidence: 62%

Metal constituents of chromatin. Interaction of mercury in vivo

Bryan¹,

Guy²,

Hardy³

1974

Biochemistry

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Metallothionein and its Involvement in Heavy Metal Induced Nephropathy

Cain¹

1987

Nephrotoxicity in the Experimental and Clinical Situation

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Stimulation of protein and RNA synthesis by methylmercury chloride in the liver of intact and adrenalectomized rats

et al. 1981

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(1) A single injection of methylmercury chloride in the rat (10-50 mg/kg) increased both in vivo and in vitro rates of 14C-leucine incorporation into the protein of the post-mitochondrial supernatant fraction of the liver. In contrast, no stimulation of protein synthesis was observed in the brain of the methylmercury-treated rats. (2) Methylmercury administration also stimulated RNA polymerase activities in isolated hepatic nuclei, stimulation of Mg-dependent activity being higher than that of Mn-dependent activity. (3) In experiments with adrenalectomized rats, it was found that the stimulatory effect of methylmercury on protein and RNA synthesis in the liver was mediated partly through the adrenal gland. (4) Analysis of serum by starch-block electrophoresis revealed that synthesis of all serum proteins, including albumin and alpha-gamma globulin fractions, was stimulated by methylmercury treatment. (5) These results suggest that the observed effects of methylmercury on the liver depend on mechanisms other than enhancement of the synthesis of acute-phase proteins.

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Partial characterization of liver proteins following exposure to mercury

Cited by 6 publications

References 6 publications

Metal constituents of chromatin. Interaction of mercury in vivo

Metal constituents of chromatin. Interaction of mercury in vivo

Metallothionein and its Involvement in Heavy Metal Induced Nephropathy

Stimulation of protein and RNA synthesis by methylmercury chloride in the liver of intact and adrenalectomized rats

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