Partial compliance in schizophrenia and the impact on patient outcomes

Llorca, Pierre‐Michel

doi:10.1016/j.psychres.2007.07.012

Cited by 148 publications

(120 citation statements)

References 77 publications

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“…Studies consistently showed that nonadherence was significantly associated with poorer outcomes, including greater risk of hospitalization [Ahn et al 2008;Eaddy et al 2005;Gilmer et al 2004;Law et al 2008;Morken et al 2008;Svarstad et al 2001;Valenstein et al 2002;Weiden et al 2004a], greater use of emergency services , longer length of hospital stay Valenstein et al 2002] and greater risk of suicide [Leucht and Heres, 2006;Llorca, 2008]. The consequences to society included having to deal with the consequences of violence , substance abuse and criminal behaviour .…”

Section: Discussionmentioning

confidence: 99%

“…For the consequences of nonadherence, another recent review [Llorca, 2008] reported that nonadherence and partial adherence can set in motion a 'downward spiral' of events resulting in inconsistent symptom control, relapse and rehospitalization, which in turn can lead to long-term functional disabilities, loss of autonomy, education or employment possibilities, homelessness, a likelihood of dropping out of care completely and even suicide. A clear link between nonadherence and an increased risk of hospitalization is found in our review; we also found support for the link between poor medication adherence and suicide risk.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Higashi¹,

Medic

Littlewood

et al. 2013

Therapeutic Advances in Psychopharmacology

479

381

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Background: Nonadherence to medication is a recognized problem and may be the most challenging aspect of treatment. Methods:We performed a systematic review of factors that influence adherence and the consequences of nonadherence to the patient, healthcare system and society, in patients with schizophrenia. Particular attention was given to the effect of nonadherence on hospitalization rates, as a key driver of increased costs of care. A qualitative systematic literature review was conducted using a broad search strategy using disease and adherence terms. Due to the large number of abstracts identified, article selection was based on studies with larger sample sizes published after 2001. Thirty-seven full papers were included: 15 studies on drivers and 22 on consequences, of which 12 assessed the link between nonadherence and hospitalization. Results: Key drivers of nonadherence included lack of insight, medication beliefs and substance abuse. Key consequences of nonadherence included greater risk of relapse, hospitalization and suicide. Factors positively related to adherence were a good therapeutic relationship with physician and perception of benefits of medication. The most frequently reported driver and consequence were lack of insight and greater risk of hospitalization respectively. Conclusions: Improving adherence in schizophrenia may have a considerable positive impact on patients and society. This can be achieved by focusing on the identified multitude of factors driving nonadherence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Higashi¹,

Medic

Littlewood

et al. 2013

Therapeutic Advances in Psychopharmacology

479

381

View full text Add to dashboard Cite

show abstract

“…However, full compliance with treatment is difficult to obtain in the majority of chronic illnesses. 45 The use of RLAI in maintenance treatment for all bipolar patients is therefore relevant. Nevertheless, the long-term gain obtained after the introduction of RLAI will be greater in patients with poor adherence to treatment.…”

Section: Patient-related Factorsmentioning

confidence: 99%

Patient perspectives on use of long-acting antipsychotics in bipolar disorder: focus on risperidone injection

Samalin

Charpeaud

Lorabi³

et al. 2010

PPA

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Abstract:In the last few years, oral second-generation antipsychotics have demonstrated mood-stabilizing properties and are now widely used in the treatment of bipolar disorder. Unfortunately, treatment of this chronic and complex illness is hampered with poor adherence on the part of patients. Long-acting injectable formulations of second-generation antipsychotics could combine the effect of oral second-generation antipsychotics in patients with bipolar disorder and the benefits of depot formulation with the assurance of steady medication delivery and thereby improve adherence. In this context, the efficacy and tolerance of risperidone long-acting injection (RLAI) for maintenance treatment in patients with bipolar disorder is assessed. The relevant studies found RLAI to be effective in preventive treatment of manic but not depressive recurrences in bipolar patients, with good tolerance. RLAI appeared to be particularly suitable for patients with known poor adherence to treatment or severe bipolar disorder (such as patients who relapse frequently). Lastly, if RLAI, unlike the first-generation antipsychotics, does not induce depressive symptoms, the different studies do not enable us to consider its use in monotherapy in the preventive treatment of patients with depressive polarity. Long-acting second-generation antipsychotics in bipolar patients are therefore associated with long-term benefits, but their use in clinical practice needs to be improved.

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“…Evidently, mental health consumers may find themselves in a perpetual pattern of illness occurrence, prescribed medication subsequently producing unendurable side effects, discontinuation of medication and eventual relapse (Llorca, 2008;Naber and Karow, 2001;Salomon and Hamilton, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic medication side effect assessment tools: A systematic review

Stomski

Morrison

Meyer

2015

Aust N Z J Psychiatry

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Objective: The aim of this systematic review was to critically appraise the psychometric properties of antipsychotic medication side effect assessment tools.Methods: Systematic searches were undertaken in PubMed, CINAHL and CENTRAL from inception to October 2014. Studies were included if they detailed the evaluation of psychometric properties of antipsychotic medication side effect assessment tools in mental health populations. Studies were excluded if they examined the use of antipsychotic medication side effect assessment tools in non-mental health populations, including people suffering from dementia, Parkinsonism and Alzheimer's. Narrative reviews and studies published in any language other than English were also excluded.Results: Content validity was appropriately established for only one of the tools, reliability was inappropriately evaluated for all but one tool, and the assessment of responsiveness was not acceptable for any tool. Conclusion:Further psychometric studies are warranted to consolidate the psychometric properties of the included antipsychotic medication side effect assessment tools before any of these tools can be confidently recommended for either research or clinical purposes.

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Partial compliance in schizophrenia and the impact on patient outcomes

Cited by 148 publications

References 77 publications

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Patient perspectives on use of long-acting antipsychotics in bipolar disorder: focus on risperidone injection

Antipsychotic medication side effect assessment tools: A systematic review

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