Partial cystectomy for urothelial carcinoma of the bladder: Practice patterns and outcomes in the general population

Leveridge, Michael; Izard, Jason; Wei, Xuejiao; Booth, Christopher M.

doi:10.5489/cuaj.4403

Cited by 6 publications

(1 citation statement)

References 22 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Ontario Cancer Registry, 3320 patients received PC and 3139 patients received RC from 1994 to 2008. Factors associated with receiving PC included older age, having moderate comorbidities, and receiving surgery outside of a comprehensive cancer center (76). After adjusting for age, comorbidity score, stage, and presence of lymphovascular invasion, PC showed comparable and statistically nonsignificant differences compared to RC, with 5-year OS (HR 0.95, 95% CI 0.79-1.14) and CSS (HR 0.87, 95% CI 0.7-1.09).…”

Section: Partial Cystectomymentioning

confidence: 99%

Bladder preservation in muscle-invasive bladder cancer: a comprehensive review

Hamad¹,

McCloskey²,

Milowsky³

et al. 2020

Int. braz j urol.

View full text Add to dashboard Cite

Background: Standard management of muscle-invasive bladder cancer involves radical cystectomy with pelvic lymph node dissection. However, patients may be ineligible for surgery or may wish to avoid the morbidity of cystectomy due to quality of life concerns. Bladder preservation therapies have emerged as alternatives treatment options that can provide comparable oncologic outcomes while maintaining patients' quality of life. Objective: To review bladder preservation therapies, patient selection criteria, and functional and oncologic outcomes for BPT in muscle-invasive bladder cancer. Materials and Methods: We conducted a comprehensive literature review of bladder preservation therapies in Pubmed and Embase. Discussion: The ideal patient for BPT has low-volume T2 disease, absence of CIS, absence of hydronephrosis, and a maximal TURBT with regular surveillance. Technological advancements involving cancer staging, TURBT technique, and chemotherapy and radiation therapy regimens have improved BPT outcomes, with oncologic outcomes now comparable to those of radical cystectomy. Advancements in BPT also includes a heightened focus on improving quality of life for patients undergoing bladder preservation. Preservation strategies with most evidence for use include trimodality therapy and partial cystectomy with pelvic lymph node dissection. Conclusions: This review highlights the breadth of strategies that aim to preserve a patient's bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the fi eld towards patient-tailored care.

show abstract

Section: Partial Cystectomymentioning

confidence: 99%