Partial Mapping of the IL-10 Promoter Region: Identification of New SNPs and Association with Tuberculosis Outcome in Brazilians

IL-10Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

“…This is not the first meta-analysis to assess the associations between three polymorphisms (-1082G/A, -819C/T, and -592A/C) in the IL-10 gene promoter and the risk of TB. We found that the results of our meta-analysis are inconsistent with a recent study of Liang, et al 39 in which some following shortcomings were found : 1) the NOS scores of 3 Chinese articles included were lower than 7 stars through quality assessment, 2) two studies that meet the inclusion criterion were excluded (Ma, et al, 28 Spinassé, et al 32 ), 3) the choice of genetic models was incorrect, 4) heterogeneity analysis and sensitivity analysis were missing, and 5) some extracted data was not accurate enough. Therefore, we performed this meta-analysis to examine the association between three IL-10 and IL-6 polymorphisms and TB risk again.…”

“…The search of the selected databases retrieved 30 potentially relevant articles, including 7800 cases and 8793 controls, according to inclusion and exclusion criteria. There are 26 case-control studies concerning IL-10 -1082G/A polymorphism, 6 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 29 30 31 32 33 34 35 15 case-control studies for IL-10 -819C/T polymorphism, 6 10 14 16 17 20 21 22 24 25 28 29 30 32 36 16 case-control studies for IL-10 -592A/C polymorphism, 6 10 14 15 16 17 20 21 24 25 26 29 30 32 33 36 and 7 case-control studies about IL-6 -174G/C polymorphism. 6 16 17 21 25 37 38 Among the 30 eligible studies, 14 of them were of Asians, 6 11 15 18 19 21 22 23 28 30 …”

“…6 16 17 21 25 37 38 Among the 30 eligible studies, 14 of them were of Asians, 6 11 15 18 19 21 22 23 28 30 31 35 37 38 6 studies were of Europeans, 12 13 16 20 25 34 6 studies were of Africans, 10 14 24 27 29 36 and 4 studies were of Americans. 17 26 32 33 The NOS scores ranged from 7 to 9, indicating that the methodological quality was generally good. The detailed characteristics of the eligible studies included in this meta-analysis are shown in Table 1 , and the genotype and allele distributions of all four polymorphisms are shown in Table 2 .…”