<i>IL-10</i>Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

Ke, Zunqiong; Liu, Yuan; Ma, Jun; Zhang, Xiaoyan; Guo, Yi; Xiong, Hui

doi:10.3349/ymj.2015.56.5.1274

Cited by 17 publications

(14 citation statements)

References 38 publications

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“…In this study, the -1082G allele appears to confer a risk for acquisition of P. falciparum infection. Similarly, IL-10 -1082GG homozygosity has been implicated as a risk factor for other diseases, for example for tuberculosis [13]. However, this was not consistent with reports from another study showing that the homozygous AA genotype as the common genotype in the population of Belem in Brazil [26].…”

Section: Discussionmentioning

confidence: 59%

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Adedoja

Hoàn

Tong

et al. 2017

Tropical Med Int Health

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Abstractobjective Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by Th1 cells and macrophages. The rationale of this study was to examine and validate possible contributions of IL-10 promoter polymorphisms in sub-Saharan Africa in children infected with either Plasmodium falciparum or Schistosoma haematobium and in children co-infected with both parasites.materials and methods A total of 309 Nigerian children aged 4-15 years were recruited. The study group consisted of individuals infected either with P. falciparum (n = 76) or S. haematobium (n = 94) in mono-infections, a group of children co-infected with both P. falciparum and S. haematobium (n = 62) and matched healthy controls (n = 77). The IL-10 promoter polymorphisms -1082G/A, -819C/T and -592C/A were genotyped by direct sequencing.results The frequencies of the IL-10 -1082GG genotype, the -1082G allele and haplotype GCC (positions -1082, -819 and -592) were higher in children infected with P. falciparum than in healthy controls, indicating that the -1082GG genotype and the -1082G allele and the GCC haplotype are associated with increased susceptibility to malaria infection (OR = 3.4, 95% CI = 1.2-10.8, P = 0.02; OR = 2.5, 95% CI = 1.1-3.4, P = 0.02; OR = 3.8, 95% CI = 2.0-7.2, P = 0.0001, respectively). Children with the -1082GG genotype had a higher parasitaemia than children with the -1082AA or -1082AG genotypes (P = 0.0017). Haplotype GCC occurred more frequently in children infected with S. haematobium, while haplotype GTA was less frequent than in controls (OR = 2.2, 95% CI = 1.2-4.4, P = 0.017 and OR = 0.1, 95% CI = 0.02-0.5, P = 0.0004, respectively). No differences in the frequencies of IL-10 promoter polymorphisms were observed between children with P. falciparum-S. haematobium co-infections and healthy controls.conclusion Although IL-10 promoter polymorphisms are not associated with P. falciparum and S. haematobium co-infection, variant -1082G/A and haplotype GCC are associated with malaria, whereas the IL-10 haplotypes GCC and GTA are associated with schistosomiasis.

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Section: Discussionmentioning

confidence: 59%

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Adedoja

Hoàn

Tong

et al. 2017

Tropical Med Int Health

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“…In the context of TB, meta-analyses suggest that polymorphisms in the IL-10 gene, specifically -1082G/A polymorphisms in Europeans and -592A/C polymorphisms in Asians are significantly associated with TB risk (340). Further, antigen-specific IL-10 production is found in pulmonary TB patients (341, 342) and along with TNF-α production can be used to reliably distinguish between latent TB and pulmonary TB (342).…”

Section: Cytokinesmentioning

confidence: 99%

Cytokines and Chemokines inMycobacterium tuberculosisInfection

et al. 2016

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Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis -infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the “goldilocks” (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.

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“…Interleukins also play important role in resistance to TB. The results obtained suggest that polymorphism of IL-10 and IL-6 is associated with the increased TB risk in the Europeans and Asians [22]. For instance, the IL-10 -1082G/A polymorphism is associated with the increased TB risk in the Europeans, while the IL-10 -819C/T and IL-10 -592A/C polymorphisms in the Asians.…”

mentioning

confidence: 74%

“…For instance, the IL-10 -1082G/A polymorphism is associated with the increased TB risk in the Europeans, while the IL-10 -819C/T and IL-10 -592A/C polymorphisms in the Asians. However, the IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians [22]. In the severe course of TB there is a decrease of interleukin-2 production (IL-2) that is responsible for macrophage activation and initiation of the interferon-γ synthesis and at the same time there is an increase of IL-10 expression that has the immunosuppressive activity [4].…”

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confidence: 99%

Human pharmacogenetic pecularities affecting the action of anti-tuberculosis medicines

Antonenko

Kresyun

Zaychenko³

et al. 2016

Klìn. farm.

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For a long time it is known about differences in efficiency and toxicity of medicines in different patients. This may be due to the genetic polymorphism of the human genes, which determine drug metabolism. In this connection, the study of the genetic polymorphism, which controls the processes of drug biotransformation in human, and its influence on the effectiveness and safety of treatment of different diseases, including tuberculosis (TB), is an important task of clinical pharmacology. The review presents the data on differences of genotypes, which determine the activity of two cytochromes (CYP) 450-CYP2E1 and CYP2C9, as well as N-acetyltransferase-2 (NAT2) for the concentration in blood of the most effective antituberculosis drugs-isoniazid and rifampicin, for efficiency and toxicity of TB treatment. It has been shown that polymorphism of the CYP2C9, CYP2E1, NAT2, GST, UGT genotype in TB patients can be used as predictors of antitubercular drug-induced liver injuries. Variation of human genes that control transcription of interleukins, interferon-γ, SLC11A1, etc., allows predicting TB susceptibility and the treatment outcome.

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IL-10Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

Cited by 17 publications

References 38 publications

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Cytokines and Chemokines inMycobacterium tuberculosisInfection

Human pharmacogenetic pecularities affecting the action of anti-tuberculosis medicines

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