Partial mastectomy with axillary lymph node dissection and radiotherapy as a new treatment modality of breast cancer (I)

Lee, H. D.; Suh, Chang‐Ok; Jung, Woo Hee; Oh, Ki Keun; Park, H. B.; S., H.; Kim, B. R.; Min, Jin Sik

doi:10.3349/ymj.1992.33.3.272

Cited by 2 publications

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“…BCT has become an acceptable alternative treatment modality to mastectomy since the 1990s in Korea. 19) In a nationwide survey of breast cancer treatment in Korea, the use of breast conserving surgery has increased from 18.7% in 1996 to 41.9% in 2004. 3,4) In our hospital, more than half (51.2%) of the patients received BCT, which was higher than the above nationwide survey results.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

Noh

Park

Huh

et al. 2008

J Korean Soc Ther Radiol Oncol

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Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment (BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,174 eligible patients, 601 (51.2%) patients received a BCT and the remaining 573 (48.8%) patients received a mastectomy. The mastectomy group of patients had significantly more cases with a larger tumor size, multicentricity, extensive intraductal component, and estrogen-and progesterone-receptor negativity. The ten-year overall survival rates (OS) of the BCT and mastectomy groups were 91.96% and 91.01%, respectively (p=0.1274). The ten-year disease-free survival rates (DFS) were 80.48% for the BCT group of patients and 84.95% for the mastectomy group of patients, respectively (p=0.8795). Conclusion:Our study shows some differences in patient characteristics between the two treatment groups. However, these differences did not result in significant survival differences.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

Noh

Park

Huh

et al. 2008

J Korean Soc Ther Radiol Oncol

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Breast conserving therapy in stage I & II breast cancer in Korea

Lee

Yoon

Koo

et al. 1997

Breast Cancer Res Treat

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A randomized clinical study of 187 patients with T1, T2 breast cancer was performed, in order to compare the effects of modified radical mastectomy (MRM) and breast conserving therapy (BCT) on breast recurrence, overall survival, and disease-free survival. One hundred eighty seven patients with T1, T2 breast cancer, admitted at Yongdong Severance Hospital from April 1991 to August 1994, were randomized into two different treatment groups. Of the 187 patients, 111 patients had received MRM and 76 had received BCT. In any of the variables considered with the exceptions of age and menopausal status, patient characteristics such as tumor size, incidence of axillary lymph node metastasis, histologic grading, and estrogen and progesterone receptor positive rate were not significantly different between the two groups (p < 0.05). Using the Kaplan-Meier Product-limit method and log-rank test, the difference of locoregional recurrence, and overall and disease-free survival, between these comparable groups was analyzed. Average follow-up period was 37.6 months. Two out of 111 MRM patients and two out of 76 BCT patients had locoregional recurrence. Only one patient who had MRM was found to have a recurrence in her opposite breast. The overall survival rates in MRM and BCT patients were, respectively 93.7% and 94.1%. Furthermore, the disease-free survival rates were, respectively, 89.2% and 93.9%. This result indicates that there were no significant differences between two groups in locoregional recurrence, and overall and disease-free survival. Having gained a better cosmetic appearance, the conservative treatment group was satisfied with the BCT. In this study, we conclude that BCT is a good alternative surgical treatment modality for T1, T2 Korean breast cancer patients, which could substitute for the more traditional MRM. However, further follow-up will be needed for long-term results.

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Partial mastectomy with axillary lymph node dissection and radiotherapy as a new treatment modality of breast cancer (I)

Cited by 2 publications

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A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

Breast conserving therapy in stage I & II breast cancer in Korea

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