2021
DOI: 10.1101/2021.04.26.441412
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Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence

Abstract: Pharmacological treatment of Duchenne Muscular Dystrophy (DMD) with histone deacetylase inhibitors (HDACi) is currently being tested in clinical trials. Pre-clinical studies performed in mdx mice - the mouse model of DMD - have shown that HDACi promote compensatory muscle regeneration, while inhibiting fibro-adipogenic degeneration, by targeting fibro-adipogenic progenitors (FAPs); however, these beneficial effects are restricted to early stages of disease progression. We show here that FAPs from late stage md… Show more

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“…TSA represses the adipogenic potential of young dystrophic FAPs while enhancing the ability of these cells to support the myogenic differentiation of MuSCs via Follistatin secretion [20]. However, the epigenetic reprogramming promoted by TSA fails in old dystrophic FAPs, suggesting that such epigenetic circuits can be robustly repressed along with the disease progression [20,204,205]. Transplantation of FAPs from regenerating young muscles restored the TSA ability to increase myofiber size in old dystrophic mice [20].…”
Section: Epigenetic Circuits Stimulating Fap Promyogenic Abilitiesmentioning
confidence: 99%
“…TSA represses the adipogenic potential of young dystrophic FAPs while enhancing the ability of these cells to support the myogenic differentiation of MuSCs via Follistatin secretion [20]. However, the epigenetic reprogramming promoted by TSA fails in old dystrophic FAPs, suggesting that such epigenetic circuits can be robustly repressed along with the disease progression [20,204,205]. Transplantation of FAPs from regenerating young muscles restored the TSA ability to increase myofiber size in old dystrophic mice [20].…”
Section: Epigenetic Circuits Stimulating Fap Promyogenic Abilitiesmentioning
confidence: 99%