Partial third nerve palsy after Measles Mumps Rubella vaccination

Abstract

BackgroundMeasles Mumps Rubella (MMR) vaccination is known to cause some serious adverse events, such as fever, rash, gland inflammation and neurologic disorders. These include third and sixth cranial nerve palsies.ResultsThe case reported describes a partial recurrent oculomotor palsy associated with systemic symptoms following MMR vaccination in a healthy young child. The oculomotor palsy did not recover completely during the follow-up.ConclusionsMost of the times, measles, mumps and rubella cause mild illness and discomfort; but can also have serious or fatal sequelae. MMR vaccination has been proved to be safe and to reduce significantly the number of reported infections due to these viruses. However, significant adverse events can occur and paediatricians and public health operators should be aware of this aspect.

Glossopharyngeal Nerve and Vagus Nerve Palsies Associated with Influenza Vaccination

“…In a cohort study, the occurrence of Bell's palsy increased significantly in association with early influenza vaccination (hazard ratio: 1.34) (6). Adverse neurological effects of vaccines other than the influenza vaccine include optic neuritis (7) and facial nerve palsy (8) caused by the anthrax vaccine, abducens nerve paralysis in children following measles, mumps, rubella (MMR) and diphtheria, pertussis, tetanus (DPT) vaccination (9) and oculomotor nerve paralysis in response to the MMR vaccine (10).…”

Claw Hand Deformity Developing After MMR Vaccination: The First Case Report

“…Bunlar, KKK aşısından sonra gelişen hemipleji, parsiyel 3. sinir paralizisi ve tekrarlayan 6. sinir felcidir. [10][11][12] Bu yan etkiler, mekanik bir etki olmadan aşının immü-nolojik etkisiyle ortaya çıkmıştır. Bunun dışında, pençe eli deformitesinin nedenleri, konjenital kusurlar, sinir hasarları, omurilik yaralanmaları ve ulnar sinir hasarı şeklinde sıralanabilir.…”

Adverse events following measles-mumps-rubella-varicella vaccine: an independent perspective on Italian pharmacovigilance data

“…More importantly, they do not question the plausibility of such an adverse reaction, because cranial nerve palsy may sometimes be the harbinger of encephalomyelitis, which may, although rarely, be caused by vaccinations. Cases of oculomotor nerve palsy occurring after MMR vaccination has already been described in the scientific literature 33 , 34 . Case 4 Case n. 23 cited in the paper of Stefanizzi et al 5 : “ The case involves a male child aged 30 months: few hours after vaccination, he developed hyperpyrexia with an episode of febrile seizure.…”

“…More importantly, they do not question the plausibility of such an adverse reaction, because cranial nerve palsy may sometimes be the harbinger of encephalomyelitis, which may, although rarely, be caused by vaccinations. Cases of oculomotor nerve palsy occurring after MMR vaccination has already been described in the scientific literature 33,34 .…”